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- W2149967181 endingPage "1050" @default.
- W2149967181 startingPage "1042" @default.
- W2149967181 abstract "With an increasingly ageing population, osteoporosis and osteoporosis-related fractures is fast becoming an important public health problem placing a considerable economic burden on health service resources. This does not account for the substantial pain, disability and indeed mortality incurred after a fracture, particularly a hip fracture. Osteoporosis is a systemic skeletal disorder which results from an imbalance in bone remodeling. This leads to a reduction in bone strength and increased susceptibility to fracture. It affects up to 1 in 2 women and 1 in 5 men. In the past 2 decades, there have been significant advances in bone biology which have helped in the understanding of the pathogenesis of osteoporosis and have led to improved therapies. In developing strategies for fracture prevention, it is important to identify those individuals with the highest fracture risk who will require pharmacological intervention. Treatment is aimed at fracture prevention and includes modification of general lifestyle factors which have been linked to fractures in epidemiological studies and ensuring optimum calcium and vitamin D intake as adjunct to active anti-fracture therapy. A number of drugs are now approved for the treatment of osteoporosis. This review article will describe the pathogenesis of osteoporosis and focus on the methods currently in use for the identification of patients at high fracture risk and will highlight their usefulness and limitations. The existing anti-fracture pharmacotherapies and those in development will be reviewed. Assessment of their effectiveness including the use of biochemical markers of bone turnover in this clinical context will be reviewed." @default.
- W2149967181 created "2016-06-24" @default.
- W2149967181 creator A5000844351 @default.
- W2149967181 creator A5052075614 @default.
- W2149967181 date "2011-09-06" @default.
- W2149967181 modified "2023-10-16" @default.
- W2149967181 title "The pathogenesis, diagnosis, investigation and management of osteoporosis" @default.
- W2149967181 cites W1582960075 @default.
- W2149967181 cites W1593442063 @default.
- W2149967181 cites W1886489026 @default.
- W2149967181 cites W1904290160 @default.
- W2149967181 cites W1964891491 @default.
- W2149967181 cites W1970447061 @default.
- W2149967181 cites W1970787765 @default.
- W2149967181 cites W1975366865 @default.
- W2149967181 cites W1983220846 @default.
- W2149967181 cites W1983364263 @default.
- W2149967181 cites W1984512053 @default.
- W2149967181 cites W1984758198 @default.
- W2149967181 cites W1985160737 @default.
- W2149967181 cites W1990771263 @default.
- W2149967181 cites W1993035292 @default.
- W2149967181 cites W1994486188 @default.
- W2149967181 cites W1996161852 @default.
- W2149967181 cites W1996563641 @default.
- W2149967181 cites W1999719776 @default.
- W2149967181 cites W2004165369 @default.
- W2149967181 cites W2004293437 @default.
- W2149967181 cites W2010029465 @default.
- W2149967181 cites W2012608865 @default.
- W2149967181 cites W2017945794 @default.
- W2149967181 cites W2022094899 @default.
- W2149967181 cites W2023676666 @default.
- W2149967181 cites W2024143452 @default.
- W2149967181 cites W2030795608 @default.
- W2149967181 cites W2035139971 @default.
- W2149967181 cites W2035416199 @default.
- W2149967181 cites W2040645421 @default.
- W2149967181 cites W2041869246 @default.
- W2149967181 cites W2043492069 @default.
- W2149967181 cites W2043685083 @default.
- W2149967181 cites W2043758876 @default.
- W2149967181 cites W2046331798 @default.
- W2149967181 cites W2048121149 @default.
- W2149967181 cites W2051096613 @default.
- W2149967181 cites W2052991153 @default.
- W2149967181 cites W2054376446 @default.
- W2149967181 cites W2057332307 @default.
- W2149967181 cites W2057622758 @default.
- W2149967181 cites W2061450074 @default.
- W2149967181 cites W2063048904 @default.
- W2149967181 cites W2066812220 @default.
- W2149967181 cites W2069798869 @default.
- W2149967181 cites W2069811152 @default.
- W2149967181 cites W2070769074 @default.
- W2149967181 cites W2075283216 @default.
- W2149967181 cites W2081140214 @default.
- W2149967181 cites W2082229075 @default.
- W2149967181 cites W2098089601 @default.
- W2149967181 cites W2099665543 @default.
- W2149967181 cites W2106649747 @default.
- W2149967181 cites W2107002319 @default.
- W2149967181 cites W2107072401 @default.
- W2149967181 cites W2107494198 @default.
- W2149967181 cites W2109567871 @default.
- W2149967181 cites W2110768118 @default.
- W2149967181 cites W2110828193 @default.
- W2149967181 cites W2110993073 @default.
- W2149967181 cites W2112590956 @default.
- W2149967181 cites W2113162921 @default.
- W2149967181 cites W2113697838 @default.
- W2149967181 cites W2113756292 @default.
- W2149967181 cites W2116605720 @default.
- W2149967181 cites W2118100789 @default.
- W2149967181 cites W2118323808 @default.
- W2149967181 cites W2118540989 @default.
- W2149967181 cites W2119062112 @default.
- W2149967181 cites W2122906075 @default.
- W2149967181 cites W2124070987 @default.
- W2149967181 cites W2128980203 @default.
- W2149967181 cites W2130440034 @default.
- W2149967181 cites W2131295941 @default.
- W2149967181 cites W2134304734 @default.
- W2149967181 cites W2135593392 @default.
- W2149967181 cites W2136292511 @default.
- W2149967181 cites W2136937961 @default.
- W2149967181 cites W2137340901 @default.
- W2149967181 cites W2138328097 @default.
- W2149967181 cites W2141805766 @default.
- W2149967181 cites W2143921117 @default.
- W2149967181 cites W2146721164 @default.
- W2149967181 cites W2147725349 @default.
- W2149967181 cites W2148849217 @default.
- W2149967181 cites W2149949422 @default.
- W2149967181 cites W2150101787 @default.
- W2149967181 cites W2150904792 @default.
- W2149967181 cites W2151825217 @default.
- W2149967181 cites W2160005424 @default.