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• W2149983668 endingPage "7243" @default.
• W2149983668 startingPage "7234" @default.
• W2149983668 abstract "Aging is associated with learning deficits and a decrease in neuronal excitability, reflected by an enhanced post-burst afterhyperpolarization (AHP), in CA1 hippocampal pyramidal neurons. To identify the current(s) underlying the AHP altered in aging neurons, whole-cell voltage-clamp recording experiments were performed in hippocampal slices from young and aging rabbits. Similar to previous reports, aging neurons were found to rest at more hyperpolarized potentials and have larger AHPs than young neurons. Given that compounds that reduce the slow outward calcium-activated potassium current (sI(AHP)), a major constituent of the AHP, also facilitate learning in aging animals, the sI(AHP) was pharmacologically isolated and characterized. Aging neurons were found to have an enhanced sI(AHP,) the amplitude of which was significantly correlated to the amplitude of the AHP (r = 0.63; p < 0.001). Thus, an enhanced sI(AHP) contributes to the enhanced AHP in aging. No differences were found in the membrane resistance, capacitance, or kinetic and voltage-dependent properties of the sI(AHP). Because enhanced AHP in aging neurons has been hypothesized to be secondary to an enhanced Ca2+ influx via the voltage-gated L-type Ca2+ channels, we further examined the sI(AHP) in the presence of an L-type Ca2+ channel blocker, nimodipine (10 microm). Nimodipine caused quantitatively greater reductions in the sI(AHP) in aging neurons than in young neurons; however, the residual sI(AHP) was still significantly larger in aging neurons than in young neurons. Our data, in conjunction with previous studies showing a correlation between the AHP and learning, suggest that the enhancement of the sI(AHP) in aging is a mechanism that contributes to age-related learning deficits." @default.
• W2149983668 created "2016-06-24" @default.
• W2149983668 creator A5003900295 @default.
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• W2149983668 creator A5038572126 @default.
• W2149983668 creator A5063517569 @default.
• W2149983668 creator A5085753613 @default.
• W2149983668 date "2002-08-15" @default.
• W2149983668 modified "2023-10-14" @default.
• W2149983668 title "Age-Related Enhancement of the Slow Outward Calcium-Activated Potassium Current in Hippocampal CA1 Pyramidal Neurons<i>In Vitro</i>" @default.
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• W2149983668 doi "https://doi.org/10.1523/jneurosci.22-16-07234.2002" @default.

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