FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150003441> ?p ?o ?g. }

• W2150003441 endingPage "926" @default.
• W2150003441 startingPage "918" @default.
• W2150003441 abstract "Multiple genetic and signaling pathway alterations underlie the development of colon cancer. We utilized genome-wide transcriptome analysis to identify important gene expression patterns following treatment with 3,3'-diindolylmethane (DIM), a natural compound derived from cruciferous vegetables, on colon cancer cells. Statistical analyses of gene expression data from DIM treated cells revealed that 692 genes were significantly upregulated, while 731 genes were down-regulated. Putative gene networks showed that several oncogenes (β-catenin, Myc and FOS) were significantly suppressed by DIM treatment. Using clinical data from colon cancer patients, activation of β-catenin was found to be significantly associated with patient prognosis by Kaplan-Meir plot analysis. We validated the mRNA and protein expression levels of c-Myc, β-catenin, and cyclin D1, all of which were significantly suppressed after DIM treatment in DLD-1 and HCT116 cells. System level characterization of our findings suggests for the first time that β-catenin and c-Myc, which are major genes involved in colon carcinogenesis, were significantly downregulated by DIM treatment in colon cancer cells. Therefore, targeting Wnt/β-catenin signaling by DIM may be an attractive strategy for the prevention and treatment of colon cancer." @default.
• W2150003441 created "2016-06-24" @default.
• W2150003441 creator A5001528283 @default.
• W2150003441 creator A5009796876 @default.
• W2150003441 creator A5054982361 @default.
• W2150003441 creator A5067526527 @default.
• W2150003441 creator A5088285528 @default.
• W2150003441 date "2015-07-17" @default.
• W2150003441 modified "2023-10-10" @default.
• W2150003441 title "Genome-wide transcriptome analysis reveals inactivation of Wnt/β-catenin by 3,3′-diindolylmethane inhibiting proliferation of colon cancer cells" @default.
• W2150003441 cites W1554815317 @default.
• W2150003441 cites W1974419333 @default.
• W2150003441 cites W1986407876 @default.
• W2150003441 cites W1988438984 @default.
• W2150003441 cites W2002280305 @default.
• W2150003441 cites W2002404925 @default.
• W2150003441 cites W2007667381 @default.
• W2150003441 cites W2009792339 @default.
• W2150003441 cites W2020024293 @default.
• W2150003441 cites W2028690524 @default.
• W2150003441 cites W2029857102 @default.
• W2150003441 cites W2037204540 @default.
• W2150003441 cites W2037388225 @default.
• W2150003441 cites W2045090755 @default.
• W2150003441 cites W2056615719 @default.
• W2150003441 cites W2057187294 @default.
• W2150003441 cites W2076007300 @default.
• W2150003441 cites W2086738288 @default.
• W2150003441 cites W2097127479 @default.
• W2150003441 cites W2101802836 @default.
• W2150003441 cites W2101995865 @default.
• W2150003441 cites W2102791979 @default.
• W2150003441 cites W2106092407 @default.
• W2150003441 cites W2106390211 @default.
• W2150003441 cites W2109242212 @default.
• W2150003441 cites W2120865735 @default.
• W2150003441 cites W2125812486 @default.
• W2150003441 cites W2133252611 @default.
• W2150003441 cites W2140121036 @default.
• W2150003441 cites W2144352887 @default.
• W2150003441 cites W2146237899 @default.
• W2150003441 cites W2150926065 @default.
• W2150003441 cites W2151390388 @default.
• W2150003441 cites W2166251636 @default.
• W2150003441 cites W2327362588 @default.
• W2150003441 cites W4229856337 @default.
• W2150003441 cites W2018283485 @default.
• W2150003441 doi "https://doi.org/10.3892/ijo.2015.3089" @default.
• W2150003441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26203047" @default.
• W2150003441 hasPublicationYear "2015" @default.
• W2150003441 type Work @default.
• W2150003441 sameAs 2150003441 @default.
• W2150003441 citedByCount "21" @default.
• W2150003441 countsByYear W21500034412016 @default.
• W2150003441 countsByYear W21500034412017 @default.
• W2150003441 countsByYear W21500034412018 @default.
• W2150003441 countsByYear W21500034412019 @default.
• W2150003441 countsByYear W21500034412020 @default.
• W2150003441 countsByYear W21500034412021 @default.
• W2150003441 countsByYear W21500034412022 @default.
• W2150003441 countsByYear W21500034412023 @default.
• W2150003441 crossrefType "journal-article" @default.
• W2150003441 hasAuthorship W2150003441A5001528283 @default.
• W2150003441 hasAuthorship W2150003441A5009796876 @default.
• W2150003441 hasAuthorship W2150003441A5054982361 @default.
• W2150003441 hasAuthorship W2150003441A5067526527 @default.
• W2150003441 hasAuthorship W2150003441A5088285528 @default.
• W2150003441 hasBestOaLocation W21500034411 @default.
• W2150003441 hasConcept C104317684 @default.
• W2150003441 hasConcept C121608353 @default.
• W2150003441 hasConcept C137620995 @default.
• W2150003441 hasConcept C150194340 @default.
• W2150003441 hasConcept C153911025 @default.
• W2150003441 hasConcept C162317418 @default.
• W2150003441 hasConcept C199835354 @default.
• W2150003441 hasConcept C2781018059 @default.
• W2150003441 hasConcept C29537977 @default.
• W2150003441 hasConcept C30145163 @default.
• W2150003441 hasConcept C502942594 @default.
• W2150003441 hasConcept C526805850 @default.
• W2150003441 hasConcept C54355233 @default.
• W2150003441 hasConcept C555283112 @default.
• W2150003441 hasConcept C86803240 @default.
• W2150003441 hasConceptScore W2150003441C104317684 @default.
• W2150003441 hasConceptScore W2150003441C121608353 @default.
• W2150003441 hasConceptScore W2150003441C137620995 @default.
• W2150003441 hasConceptScore W2150003441C150194340 @default.
• W2150003441 hasConceptScore W2150003441C153911025 @default.
• W2150003441 hasConceptScore W2150003441C162317418 @default.
• W2150003441 hasConceptScore W2150003441C199835354 @default.
• W2150003441 hasConceptScore W2150003441C2781018059 @default.
• W2150003441 hasConceptScore W2150003441C29537977 @default.
• W2150003441 hasConceptScore W2150003441C30145163 @default.
• W2150003441 hasConceptScore W2150003441C502942594 @default.
• W2150003441 hasConceptScore W2150003441C526805850 @default.
• W2150003441 hasConceptScore W2150003441C54355233 @default.
• W2150003441 hasConceptScore W2150003441C555283112 @default.
• W2150003441 hasConceptScore W2150003441C86803240 @default.

• next