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- W2150015314 endingPage "20130106" @default.
- W2150015314 startingPage "20130106" @default.
- W2150015314 abstract "The outcome of a malignant disease depends on the efficacy of the immune system to destroy cancer cells. Key steps in this process, for example the generation of a proper Ca 2+ signal induced by recognition of a specific antigen, are regulated by various ion channel including voltage-gated Kv1.3 and Ca 2+ -activated KCa3.1 K + channels, and the interplay between Orai and STIM to produce the Ca 2+ -release-activated Ca 2+ (CRAC) current required for T-cell proliferation and function. Understanding the immune cell subset-specific expression of ion channels along with their particular function in a given cell type, and the role of cancer tissue-dependent factors in the regulation of operation of these ion channels are emerging questions to be addressed in the fight against cancer disease. Answering these questions might lead to a better understanding of the immunosuppression phenomenon in cancer tissue and the development of drugs aimed at skewing the distribution of immune cell types towards killing of the tumour cells." @default.
- W2150015314 created "2016-06-24" @default.
- W2150015314 creator A5014582592 @default.
- W2150015314 creator A5052648785 @default.
- W2150015314 creator A5085196030 @default.
- W2150015314 date "2014-03-19" @default.
- W2150015314 modified "2023-10-16" @default.
- W2150015314 title "Ion channels and anti-cancer immunity" @default.
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- W2150015314 doi "https://doi.org/10.1098/rstb.2013.0106" @default.
- W2150015314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3917360" @default.
- W2150015314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24493754" @default.
- W2150015314 hasPublicationYear "2014" @default.
- W2150015314 type Work @default.