FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150056483> ?p ?o ?g. }

• W2150056483 endingPage "e91248" @default.
• W2150056483 startingPage "e91248" @default.
• W2150056483 abstract "The blockade of glucocorticoid (GC) action through antagonism of the glucocorticoid receptor II (GRII) has been used to minimize the undesirable effects of chronically elevated GC levels. Mifepristone (RU486) is known to competitively block GRII action, but not exclusively, as it antagonizes the progesterone receptor. A number of new selective GRII antagonists have been developed, but limited testing has been completed in animal models of overt type 2 diabetes mellitus. Therefore, two selective GRII antagonists (C113176 and C108297) were tested to determine their effects in our model of GC-induced rapid-onset diabetes (ROD). Male Sprague-Dawley rats (∼ six weeks of age) were placed on a high-fat diet (60%), surgically implanted with pellets containing corticosterone (CORT) or wax (control) and divided into five treatment groups. Each group was treated with either a GRII antagonist or vehicle for 14 days after surgery: CORT pellets (400 mg/rat) + antagonists (80 mg/kg/day); CORT pellets + drug vehicle; and wax pellets (control) + drug vehicle. After 10 days of CORT treatment, body mass gain was increased with RU486 (by ∼20% from baseline) and maintained with C113176 administration, whereas rats given C108297 had similar body mass loss (∼15%) to ROD animals. Fasting glycemia was elevated in the ROD animals (>20 mM), normalized completely in animals treated with RU486 (6.2±0.1 mM, p<0.05) and improved in animals treated with C108297 and C113176 (14.0±1.6 and 8.8±1.6 mM, p<0.05 respectively). Glucose intolerance was normalized with RU486 treatment, whereas acute insulin response was improved with RU486 and C113176 treatment. Also, peripheral insulin resistance was attenuated with C113176 treatment along with improved levels of β-cell function while C108297 antagonism only provided modest improvements. In summary, C113176 is an effective agent that minimized some GC-induced detrimental metabolic effects and may provide an alternative to the effective, but non-selective, GRII antagonist RU486." @default.
• W2150056483 created "2016-06-24" @default.
• W2150056483 creator A5010207048 @default.
• W2150056483 creator A5012190979 @default.
• W2150056483 creator A5021797319 @default.
• W2150056483 creator A5042351326 @default.
• W2150056483 creator A5055548172 @default.
• W2150056483 creator A5070917278 @default.
• W2150056483 creator A5075661431 @default.
• W2150056483 date "2014-03-18" @default.
• W2150056483 modified "2023-10-16" @default.
• W2150056483 title "Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats" @default.
• W2150056483 cites W1555460575 @default.
• W2150056483 cites W1680099832 @default.
• W2150056483 cites W1970259819 @default.
• W2150056483 cites W1975232668 @default.
• W2150056483 cites W1976089177 @default.
• W2150056483 cites W1978393827 @default.
• W2150056483 cites W1979139803 @default.
• W2150056483 cites W1983091277 @default.
• W2150056483 cites W1983119991 @default.
• W2150056483 cites W1986798119 @default.
• W2150056483 cites W1989989685 @default.
• W2150056483 cites W1993073314 @default.
• W2150056483 cites W1997103341 @default.
• W2150056483 cites W1998129602 @default.
• W2150056483 cites W1998817848 @default.
• W2150056483 cites W1999429145 @default.
• W2150056483 cites W2001183689 @default.
• W2150056483 cites W2001786352 @default.
• W2150056483 cites W2005344166 @default.
• W2150056483 cites W2008782804 @default.
• W2150056483 cites W2015954445 @default.
• W2150056483 cites W2020659754 @default.
• W2150056483 cites W2021271765 @default.
• W2150056483 cites W2030386607 @default.
• W2150056483 cites W2032957128 @default.
• W2150056483 cites W2033874572 @default.
• W2150056483 cites W2042443117 @default.
• W2150056483 cites W2069716391 @default.
• W2150056483 cites W2078881833 @default.
• W2150056483 cites W2079620052 @default.
• W2150056483 cites W2086453900 @default.
• W2150056483 cites W2087816003 @default.
• W2150056483 cites W2091831018 @default.
• W2150056483 cites W2098274706 @default.
• W2150056483 cites W209938675 @default.
• W2150056483 cites W2105271089 @default.
• W2150056483 cites W2106964822 @default.
• W2150056483 cites W2108963149 @default.
• W2150056483 cites W2122739068 @default.
• W2150056483 cites W2124620553 @default.
• W2150056483 cites W2128569914 @default.
• W2150056483 cites W2133256471 @default.
• W2150056483 cites W2137921442 @default.
• W2150056483 cites W2145137221 @default.
• W2150056483 cites W2149251756 @default.
• W2150056483 cites W2150234966 @default.
• W2150056483 cites W2150691073 @default.
• W2150056483 cites W2156518031 @default.
• W2150056483 cites W2156866593 @default.
• W2150056483 cites W2161453823 @default.
• W2150056483 cites W2161618887 @default.
• W2150056483 cites W2164141618 @default.
• W2150056483 cites W2168380873 @default.
• W2150056483 cites W2171303876 @default.
• W2150056483 cites W2331459600 @default.
• W2150056483 doi "https://doi.org/10.1371/journal.pone.0091248" @default.
• W2150056483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3958344" @default.
• W2150056483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24642683" @default.
• W2150056483 hasPublicationYear "2014" @default.
• W2150056483 type Work @default.
• W2150056483 sameAs 2150056483 @default.
• W2150056483 citedByCount "28" @default.
• W2150056483 countsByYear W21500564832015 @default.
• W2150056483 countsByYear W21500564832016 @default.
• W2150056483 countsByYear W21500564832017 @default.
• W2150056483 countsByYear W21500564832018 @default.
• W2150056483 countsByYear W21500564832019 @default.
• W2150056483 countsByYear W21500564832020 @default.
• W2150056483 countsByYear W21500564832021 @default.
• W2150056483 countsByYear W21500564832023 @default.
• W2150056483 crossrefType "journal-article" @default.
• W2150056483 hasAuthorship W2150056483A5010207048 @default.
• W2150056483 hasAuthorship W2150056483A5012190979 @default.
• W2150056483 hasAuthorship W2150056483A5021797319 @default.
• W2150056483 hasAuthorship W2150056483A5042351326 @default.
• W2150056483 hasAuthorship W2150056483A5055548172 @default.
• W2150056483 hasAuthorship W2150056483A5070917278 @default.
• W2150056483 hasAuthorship W2150056483A5075661431 @default.
• W2150056483 hasBestOaLocation W21500564831 @default.
• W2150056483 hasConcept C126322002 @default.
• W2150056483 hasConcept C134018914 @default.
• W2150056483 hasConcept C170493617 @default.
• W2150056483 hasConcept C2776885963 @default.
• W2150056483 hasConcept C2777383412 @default.
• W2150056483 hasConcept C2778122271 @default.
• W2150056483 hasConcept C2778826759 @default.

• next