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- W2150059080 abstract "A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a cascade of intracellular components that mediate its effects, plays a major role in the regulation of skeletal muscle growth. A central component in this cascade is the kinase Akt, also called protein kinase B (PKB), which controls both protein synthesis, via the kinases mammalian target of rapamycin (mTOR) and glycogen synthase kinase 3β (GSK3β), and protein degradation, via the transcription factors of the FoxO family. In this paper, we review the composition and function of this pathway in skeletal muscle fibers, focusing on evidence obtained in vivo by transgenic and knockout models and by muscle transient transfection experiments. Although this pathway is essential for muscle growth during development and regeneration, its role in adult muscle response to mechanical load is less clear. A full understanding of the operation of this pathway could help to design molecularly targeted therapeutics aimed at preventing muscle wasting, which occurs in a variety of pathologic contexts and in the course of aging." @default.
- W2150059080 created "2016-06-24" @default.
- W2150059080 creator A5052509314 @default.
- W2150059080 creator A5073596294 @default.
- W2150059080 date "2011-01-01" @default.
- W2150059080 modified "2023-10-10" @default.
- W2150059080 title "Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models" @default.
- W2150059080 cites W1495096570 @default.
- W2150059080 cites W1519982502 @default.
- W2150059080 cites W1530473805 @default.
- W2150059080 cites W1562705858 @default.
- W2150059080 cites W1567217814 @default.
- W2150059080 cites W1567219202 @default.
- W2150059080 cites W1586159393 @default.
- W2150059080 cites W1672030686 @default.
- W2150059080 cites W1697523131 @default.
- W2150059080 cites W172002323 @default.
- W2150059080 cites W1899306331 @default.
- W2150059080 cites W1906543545 @default.
- W2150059080 cites W1966333337 @default.
- W2150059080 cites W1966530677 @default.
- W2150059080 cites W1971857747 @default.
- W2150059080 cites W1972880994 @default.
- W2150059080 cites W1973622869 @default.
- W2150059080 cites W1975217943 @default.
- W2150059080 cites W1977548231 @default.
- W2150059080 cites W1978811843 @default.
- W2150059080 cites W1982450147 @default.
- W2150059080 cites W1984621921 @default.
- W2150059080 cites W1985534077 @default.
- W2150059080 cites W1989324173 @default.
- W2150059080 cites W1993672117 @default.
- W2150059080 cites W1993835711 @default.
- W2150059080 cites W1993876923 @default.
- W2150059080 cites W1998060705 @default.
- W2150059080 cites W1998763810 @default.
- W2150059080 cites W2000731858 @default.
- W2150059080 cites W2004582874 @default.
- W2150059080 cites W2005101201 @default.
- W2150059080 cites W2007530728 @default.
- W2150059080 cites W2009313095 @default.
- W2150059080 cites W2011282245 @default.
- W2150059080 cites W2016815316 @default.
- W2150059080 cites W2017949036 @default.
- W2150059080 cites W2024895769 @default.
- W2150059080 cites W2025176940 @default.
- W2150059080 cites W2025192214 @default.
- W2150059080 cites W2029206414 @default.
- W2150059080 cites W2029810183 @default.
- W2150059080 cites W2029816532 @default.
- W2150059080 cites W2033429522 @default.
- W2150059080 cites W2033676599 @default.
- W2150059080 cites W2033797333 @default.
- W2150059080 cites W2033924360 @default.
- W2150059080 cites W2035555824 @default.
- W2150059080 cites W2036787961 @default.
- W2150059080 cites W2037341437 @default.
- W2150059080 cites W2038988941 @default.
- W2150059080 cites W2039825798 @default.
- W2150059080 cites W2040143421 @default.
- W2150059080 cites W2042628823 @default.
- W2150059080 cites W2045736879 @default.
- W2150059080 cites W2046911380 @default.
- W2150059080 cites W2053073281 @default.
- W2150059080 cites W2053079324 @default.
- W2150059080 cites W2054121324 @default.
- W2150059080 cites W2055492254 @default.
- W2150059080 cites W2056158543 @default.
- W2150059080 cites W2058896449 @default.
- W2150059080 cites W2059471982 @default.
- W2150059080 cites W2061929833 @default.
- W2150059080 cites W2067765926 @default.
- W2150059080 cites W2068382528 @default.
- W2150059080 cites W2071996542 @default.
- W2150059080 cites W2081920342 @default.
- W2150059080 cites W2084328324 @default.
- W2150059080 cites W2087962053 @default.
- W2150059080 cites W2092740654 @default.
- W2150059080 cites W2093832185 @default.
- W2150059080 cites W2097739600 @default.
- W2150059080 cites W2099767283 @default.
- W2150059080 cites W2100688137 @default.
- W2150059080 cites W2105048034 @default.
- W2150059080 cites W2105412616 @default.
- W2150059080 cites W2106883683 @default.
- W2150059080 cites W2108360575 @default.
- W2150059080 cites W2111681103 @default.
- W2150059080 cites W2111894013 @default.
- W2150059080 cites W2113265855 @default.
- W2150059080 cites W2114927063 @default.
- W2150059080 cites W2115645521 @default.
- W2150059080 cites W2116668508 @default.
- W2150059080 cites W2116738170 @default.
- W2150059080 cites W2116756051 @default.
- W2150059080 cites W2117403660 @default.
- W2150059080 cites W2118469376 @default.
- W2150059080 cites W2119123604 @default.
- W2150059080 cites W2119979409 @default.