Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150085616> ?p ?o ?g. }
- W2150085616 endingPage "451" @default.
- W2150085616 startingPage "442" @default.
- W2150085616 abstract "Mucositis is a serious disorder of the gastrointestinal tract that results from cancer chemotherapy. We investigated the protective effects of silymarin on epirubicin-induced mucosal barrier injury in CD-1 mice. Immunohistochemical activity of both pro-apoptotic Bax and anti-apoptotic Bcl-2 markers, together with p53, cyt-P450 expression and DNA damage analysis on stomach, small intestine and colon were evaluated. Our results indicated stronger expression for cyt P450 in all analyzed gastrointestinal tissues of Epi group, which demonstrate intense drug detoxification. Bax immunopositivity was intense in the absorptive enterocytes and lamina connective cells of the small intestine, surface epithelial cells of the stomach and also in the colonic epithelium and lamina concomitant with a decreased Bcl-2 expression in all analyzed tissues. Epirubicin-induced gastrointestinal damage was verified by a goblet cell count and morphology analysis on histopathological sections stained for mucins. In all analyzed tissues, Bax immunopositivity has been withdrawn by highest dose of silymarin concomitant with reversal of Bcl-2 intensity at a level comparable with control. p53 expression was found in all analyzed tissues and decreased by high dose of silymarin. Also, DNA internucleosomal fragmentation was observed in the Epi groups for all analyzed tissues was almost suppressed at 100 mg/kg Sy co-treatment. Histological aspect and goblet cell count were restored at a highest dose of Sy for both small and large intestine. In conclusion, our findings suggest that silymarin may prevent cellular damage of epirubicin-induced toxicity and was effective in reducing the severity indicators of gastrointestinal mucositis in mice." @default.
- W2150085616 created "2016-06-24" @default.
- W2150085616 creator A5002960509 @default.
- W2150085616 creator A5011339306 @default.
- W2150085616 creator A5017414544 @default.
- W2150085616 creator A5019064842 @default.
- W2150085616 creator A5036010020 @default.
- W2150085616 creator A5041560971 @default.
- W2150085616 creator A5043435630 @default.
- W2150085616 creator A5053831853 @default.
- W2150085616 creator A5080387413 @default.
- W2150085616 date "2015-01-22" @default.
- W2150085616 modified "2023-10-18" @default.
- W2150085616 title "Protective effects of silymarin on epirubicin-induced mucosal barrier injury of the gastrointestinal tract" @default.
- W2150085616 cites W1823197934 @default.
- W2150085616 cites W1824579594 @default.
- W2150085616 cites W1976555669 @default.
- W2150085616 cites W1976570855 @default.
- W2150085616 cites W1976971060 @default.
- W2150085616 cites W1987118233 @default.
- W2150085616 cites W1987607088 @default.
- W2150085616 cites W1987759215 @default.
- W2150085616 cites W1989429068 @default.
- W2150085616 cites W2003761115 @default.
- W2150085616 cites W2008217170 @default.
- W2150085616 cites W2012972697 @default.
- W2150085616 cites W2019094911 @default.
- W2150085616 cites W2026305160 @default.
- W2150085616 cites W2029709636 @default.
- W2150085616 cites W2040321844 @default.
- W2150085616 cites W2044189061 @default.
- W2150085616 cites W2052583992 @default.
- W2150085616 cites W2052595220 @default.
- W2150085616 cites W2056516171 @default.
- W2150085616 cites W2067089217 @default.
- W2150085616 cites W2069182261 @default.
- W2150085616 cites W2073003731 @default.
- W2150085616 cites W2077569937 @default.
- W2150085616 cites W2085633139 @default.
- W2150085616 cites W2086938391 @default.
- W2150085616 cites W2088027529 @default.
- W2150085616 cites W2089930141 @default.
- W2150085616 cites W2097640610 @default.
- W2150085616 cites W2106528813 @default.
- W2150085616 cites W2107611570 @default.
- W2150085616 cites W2107637968 @default.
- W2150085616 cites W2113108113 @default.
- W2150085616 cites W2116347275 @default.
- W2150085616 cites W2123901936 @default.
- W2150085616 cites W2128366998 @default.
- W2150085616 cites W2131506624 @default.
- W2150085616 cites W2132101919 @default.
- W2150085616 cites W2139947047 @default.
- W2150085616 cites W2144013444 @default.
- W2150085616 cites W2155635155 @default.
- W2150085616 cites W2169816885 @default.
- W2150085616 cites W2178554985 @default.
- W2150085616 cites W4231172655 @default.
- W2150085616 cites W560308733 @default.
- W2150085616 doi "https://doi.org/10.3109/01480545.2014.992072" @default.
- W2150085616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25609004" @default.
- W2150085616 hasPublicationYear "2015" @default.
- W2150085616 type Work @default.
- W2150085616 sameAs 2150085616 @default.
- W2150085616 citedByCount "16" @default.
- W2150085616 countsByYear W21500856162016 @default.
- W2150085616 countsByYear W21500856162017 @default.
- W2150085616 countsByYear W21500856162018 @default.
- W2150085616 countsByYear W21500856162020 @default.
- W2150085616 countsByYear W21500856162021 @default.
- W2150085616 countsByYear W21500856162022 @default.
- W2150085616 countsByYear W21500856162023 @default.
- W2150085616 crossrefType "journal-article" @default.
- W2150085616 hasAuthorship W2150085616A5002960509 @default.
- W2150085616 hasAuthorship W2150085616A5011339306 @default.
- W2150085616 hasAuthorship W2150085616A5017414544 @default.
- W2150085616 hasAuthorship W2150085616A5019064842 @default.
- W2150085616 hasAuthorship W2150085616A5036010020 @default.
- W2150085616 hasAuthorship W2150085616A5041560971 @default.
- W2150085616 hasAuthorship W2150085616A5043435630 @default.
- W2150085616 hasAuthorship W2150085616A5053831853 @default.
- W2150085616 hasAuthorship W2150085616A5080387413 @default.
- W2150085616 hasConcept C126322002 @default.
- W2150085616 hasConcept C142724271 @default.
- W2150085616 hasConcept C143425029 @default.
- W2150085616 hasConcept C185592680 @default.
- W2150085616 hasConcept C190283241 @default.
- W2150085616 hasConcept C204232928 @default.
- W2150085616 hasConcept C2775941134 @default.
- W2150085616 hasConcept C2776694085 @default.
- W2150085616 hasConcept C2776755627 @default.
- W2150085616 hasConcept C2777310793 @default.
- W2150085616 hasConcept C2777882243 @default.
- W2150085616 hasConcept C2778496288 @default.
- W2150085616 hasConcept C2779422922 @default.
- W2150085616 hasConcept C2780512811 @default.
- W2150085616 hasConcept C2780835546 @default.
- W2150085616 hasConcept C29730261 @default.