FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150116170> ?p ?o ?g. }

• W2150116170 endingPage "4960" @default.
• W2150116170 startingPage "4954" @default.
• W2150116170 abstract "ABSTRACT Lipopolysaccharide (LPS) is an amphipathic macromolecule that is highly aggregated in aqueous preparations. LPS-binding protein (LBP) catalyzes the transfer of single LPS molecules, segregated from an LPS aggregate, to high-density lipoproteins (HDL), which results in the neutralization of LPS. When fluorescein isothiocyanate-labeled LPS (FITC-LPS) is used, this transfer of LPS monomers to HDL can be measured as an increase in fluorescence due to dequenching of FITC-LPS. Recently, serum amyloid P component (SAP) was shown to neutralize LPS in vitro, although only in the presence of low concentrations of LBP. In this study, we show that SAP prevented HDL-mediated dequenching of FITC-LPS, even in the presence of high concentrations of LBP. Human bactericidal/permeability-increasing protein (BPI), a very potent LPS-binding and -neutralizing protein, also prevented HDL-mediated dequenching of FITC-LPS. Furthermore, SAP inhibited HDL-mediated neutralization of both rough and smooth LPS in a chemiluminescence assay quantifying the LPS-induced priming of neutrophils in human blood. SAP bound both isolated HDL and HDL in serum. Using HDL-coated magnetic beads prebound with SAP, we demonstrated that HDL-bound SAP prevented the binding of LPS to HDL. We suggest that SAP, by preventing LPS binding to HDL, plays a regulatory role, balancing the amount of LPS that, via HDL, is directed to the adrenal glands." @default.
• W2150116170 created "2016-06-24" @default.
• W2150116170 creator A5005223998 @default.
• W2150116170 creator A5048083002 @default.
• W2150116170 creator A5058123402 @default.
• W2150116170 creator A5085753329 @default.
• W2150116170 date "2000-09-01" @default.
• W2150116170 modified "2023-10-02" @default.
• W2150116170 title "Serum Amyloid P Component Prevents High-Density Lipoprotein-Mediated Neutralization of Lipopolysaccharide" @default.
• W2150116170 cites W1490300324 @default.
• W2150116170 cites W1507194547 @default.
• W2150116170 cites W1510155660 @default.
• W2150116170 cites W1590341944 @default.
• W2150116170 cites W1606581707 @default.
• W2150116170 cites W1764721577 @default.
• W2150116170 cites W1902522373 @default.
• W2150116170 cites W1902575064 @default.
• W2150116170 cites W1926076964 @default.
• W2150116170 cites W1944260161 @default.
• W2150116170 cites W1975454948 @default.
• W2150116170 cites W1978926805 @default.
• W2150116170 cites W1998440525 @default.
• W2150116170 cites W2015517035 @default.
• W2150116170 cites W2020361370 @default.
• W2150116170 cites W2021418970 @default.
• W2150116170 cites W2028653252 @default.
• W2150116170 cites W2033189690 @default.
• W2150116170 cites W2038318534 @default.
• W2150116170 cites W2039537157 @default.
• W2150116170 cites W2044343704 @default.
• W2150116170 cites W2053706055 @default.
• W2150116170 cites W2067294390 @default.
• W2150116170 cites W2069637967 @default.
• W2150116170 cites W2081704220 @default.
• W2150116170 cites W2096478292 @default.
• W2150116170 cites W2097310310 @default.
• W2150116170 cites W2106161615 @default.
• W2150116170 cites W2126359905 @default.
• W2150116170 cites W2129319296 @default.
• W2150116170 cites W2141216632 @default.
• W2150116170 cites W2144571843 @default.
• W2150116170 cites W2158092179 @default.
• W2150116170 cites W2166648967 @default.
• W2150116170 cites W2169228758 @default.
• W2150116170 cites W2170495397 @default.
• W2150116170 cites W2184869851 @default.
• W2150116170 cites W2290375429 @default.
• W2150116170 cites W2429350769 @default.
• W2150116170 doi "https://doi.org/10.1128/iai.68.9.4954-4960.2000" @default.
• W2150116170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/101709" @default.
• W2150116170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10948110" @default.
• W2150116170 hasPublicationYear "2000" @default.
• W2150116170 type Work @default.
• W2150116170 sameAs 2150116170 @default.
• W2150116170 citedByCount "16" @default.
• W2150116170 countsByYear W21501161702012 @default.
• W2150116170 countsByYear W21501161702015 @default.
• W2150116170 countsByYear W21501161702016 @default.
• W2150116170 countsByYear W21501161702017 @default.
• W2150116170 countsByYear W21501161702023 @default.
• W2150116170 crossrefType "journal-article" @default.
• W2150116170 hasAuthorship W2150116170A5005223998 @default.
• W2150116170 hasAuthorship W2150116170A5048083002 @default.
• W2150116170 hasAuthorship W2150116170A5058123402 @default.
• W2150116170 hasAuthorship W2150116170A5085753329 @default.
• W2150116170 hasBestOaLocation W21501161702 @default.
• W2150116170 hasConcept C121332964 @default.
• W2150116170 hasConcept C14086860 @default.
• W2150116170 hasConcept C159654299 @default.
• W2150116170 hasConcept C170493617 @default.
• W2150116170 hasConcept C185592680 @default.
• W2150116170 hasConcept C202751555 @default.
• W2150116170 hasConcept C203014093 @default.
• W2150116170 hasConcept C2776822972 @default.
• W2150116170 hasConcept C2776914184 @default.
• W2150116170 hasConcept C2777019933 @default.
• W2150116170 hasConcept C2778163477 @default.
• W2150116170 hasConcept C2778513237 @default.
• W2150116170 hasConcept C2778754761 @default.
• W2150116170 hasConcept C2780072125 @default.
• W2150116170 hasConcept C55359608 @default.
• W2150116170 hasConcept C55493867 @default.
• W2150116170 hasConcept C62520636 @default.
• W2150116170 hasConcept C86803240 @default.
• W2150116170 hasConcept C91881484 @default.
• W2150116170 hasConceptScore W2150116170C121332964 @default.
• W2150116170 hasConceptScore W2150116170C14086860 @default.
• W2150116170 hasConceptScore W2150116170C159654299 @default.
• W2150116170 hasConceptScore W2150116170C170493617 @default.
• W2150116170 hasConceptScore W2150116170C185592680 @default.
• W2150116170 hasConceptScore W2150116170C202751555 @default.
• W2150116170 hasConceptScore W2150116170C203014093 @default.
• W2150116170 hasConceptScore W2150116170C2776822972 @default.
• W2150116170 hasConceptScore W2150116170C2776914184 @default.
• W2150116170 hasConceptScore W2150116170C2777019933 @default.
• W2150116170 hasConceptScore W2150116170C2778163477 @default.
• W2150116170 hasConceptScore W2150116170C2778513237 @default.
• W2150116170 hasConceptScore W2150116170C2778754761 @default.

• next