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• W2150122265 abstract "Nitrogen assimilation plays a vital role in plant metabolism. Assimilation of nitrate, the primary source of nitrogen in soil, is linked to the generation of the redox signal nitric oxide (NO). An important mechanism by which NO regulates plant development and stress responses is through S-nitrosylation, that is, covalent attachment of NO to cysteine residues to form S-nitrosothiols (SNO). Despite the importance of nitrogen assimilation and NO signalling, it remains largely unknown how these pathways are interconnected. Here we show that SNO signalling suppresses both nitrate uptake and reduction by transporters and reductases, respectively, to fine tune nitrate homeostasis. Moreover, NO derived from nitrate assimilation suppresses the redox enzyme S-nitrosoglutathione Reductase 1 (GSNOR1) by S-nitrosylation, preventing scavenging of S-nitrosoglutathione, a major cellular bio-reservoir of NO. Hence, our data demonstrates that (S)NO controls its own generation and scavenging by modulating nitrate assimilation and GSNOR1 activity. Assimilation of nitrate by plant roots leads to the generation of the signalling molecule, nitric oxide. Here Frungillo et al.show that nitric oxide fine-tunes nitrate homeostasis by feedback regulating nitrate transporters and reductases, while also promoting its own storage." @default.
• W2150122265 created "2016-06-24" @default.
• W2150122265 creator A5063016242 @default.
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• W2150122265 creator A5072265496 @default.
• W2150122265 creator A5082104744 @default.
• W2150122265 date "2014-11-11" @default.
• W2150122265 modified "2023-10-18" @default.
• W2150122265 title "S-nitrosothiols regulate nitric oxide production and storage in plants through the nitrogen assimilation pathway" @default.
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• W2150122265 doi "https://doi.org/10.1038/ncomms6401" @default.
• W2150122265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4229994" @default.
• W2150122265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25384398" @default.
• W2150122265 hasPublicationYear "2014" @default.
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