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• W2150124834 startingPage "17312" @default.
• W2150124834 abstract "The low density lipoprotein receptor (LDLR) is crucial for cholesterol homeostasis and deficiency in LDLR functions cause hypercholesterolemia. LDLR is a type I transmembrane protein that requires O-glycosylation for stable expression at the cell surface. It has previously been suggested that LDLR O-glycosylation is found N-terminal to the juxtamembrane region. Recently we identified O-glycosylation sites in the linker regions between the characteristic LDLR class A repeats in several LDLR-related receptors using the SimpleCell O-glycoproteome shotgun strategy. Herein, we have systematically characterized O-glycosylation sites on recombinant LDLR shed from HEK293 SimpleCells and CHO wild-type cells. We find that the short linker regions between LDLR class A repeats contain an evolutionarily conserved O-glycosylation site at position -1 of the first cysteine residue of most repeats, which in wild-type CHO cells is glycosylated with the typical sialylated core 1 structure. The glycosites in linker regions of LDLR class A repeats are conserved in LDLR from man to Xenopus and found in other homologous receptors. O-Glycosylation is controlled by a large family of polypeptide GalNAc transferases. Probing into which isoform(s) contributed to glycosylation of the linker regions of the LDLR class A repeats by in vitro enzyme assays suggested a major role of GalNAc-T11. This was supported by expression of LDLR in HEK293 cells, where knock-out of the GalNAc-T11 isoform resulted in the loss of glycosylation of three of four linker regions." @default.
• W2150124834 created "2016-06-24" @default.
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• W2150124834 date "2014-06-01" @default.
• W2150124834 modified "2023-09-30" @default.
• W2150124834 title "Low Density Lipoprotein Receptor Class A Repeats Are O-Glycosylated in Linker Regions" @default.
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• W2150124834 doi "https://doi.org/10.1074/jbc.m113.545053" @default.
• W2150124834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4067166" @default.
• W2150124834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24798328" @default.
• W2150124834 hasPublicationYear "2014" @default.
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