FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150142981> ?p ?o ?g. }

• W2150142981 endingPage "1469" @default.
• W2150142981 startingPage "1469" @default.
• W2150142981 abstract "Genetic circuits composed of coupled positive and negative feedback loops have been shown to occur as common motifs in natural oscillatory networks. Recent work in synthetic biology has begun to demonstrate how the properties and architectures of these circuits affect their behavior. Expanding on this work, we constructed a new implementation of a common coupled feedback loop architecture by incorporating the LuxR transcriptional activator as the positive feedback element. We found that the properties of the LuxR activator had a significant impact on the observed behavior of the coupled feedback loop circuit, as a slow degradation rate of LuxR led to its accumulation after initial circuit induction. Due to this accumulation, the presence of feedback on LuxR did not greatly alter the oscillatory behavior of the circuit from a control consisting of an independent negative feedback loop, with both systems showing oscillatory responses in 30–40% of the measured cells and highly variable periods. While the oscillatory properties of individual cells were not influenced by induction levels, the percentage of cells that demonstrated oscillations was. Slight improvements to the initial responses of the coupled feedback loop circuit were also obtained by coexpression of the GroE chaperones due to improved LuxR folding. These findings illustrate the importance that positive feedback has on the tunability and robustness of coupled feedback loop oscillators, and improve our understanding of how the behavior of these systems is impacted upon by their components' properties." @default.
• W2150142981 created "2016-06-24" @default.
• W2150142981 creator A5058844502 @default.
• W2150142981 creator A5072298561 @default.
• W2150142981 date "2010-01-01" @default.
• W2150142981 modified "2023-09-27" @default.
• W2150142981 title "Slow activator degradation reduces the robustness of a coupled feedback loop oscillator" @default.
• W2150142981 cites W1483747674 @default.
• W2150142981 cites W1518061853 @default.
• W2150142981 cites W1540505601 @default.
• W2150142981 cites W1641228030 @default.
• W2150142981 cites W1703657909 @default.
• W2150142981 cites W1767475163 @default.
• W2150142981 cites W1971327350 @default.
• W2150142981 cites W1975222498 @default.
• W2150142981 cites W1975858036 @default.
• W2150142981 cites W1981560281 @default.
• W2150142981 cites W1982353649 @default.
• W2150142981 cites W1990121351 @default.
• W2150142981 cites W1993592538 @default.
• W2150142981 cites W1994373703 @default.
• W2150142981 cites W1995538422 @default.
• W2150142981 cites W1996371826 @default.
• W2150142981 cites W2007769474 @default.
• W2150142981 cites W2014150977 @default.
• W2150142981 cites W2027113296 @default.
• W2150142981 cites W2030640688 @default.
• W2150142981 cites W2039931639 @default.
• W2150142981 cites W2051497876 @default.
• W2150142981 cites W2103741616 @default.
• W2150142981 cites W2108493072 @default.
• W2150142981 cites W2123097315 @default.
• W2150142981 cites W2125937596 @default.
• W2150142981 cites W2126644712 @default.
• W2150142981 cites W2132828256 @default.
• W2150142981 cites W2136956492 @default.
• W2150142981 cites W2141997480 @default.
• W2150142981 cites W2148879985 @default.
• W2150142981 cites W2150114634 @default.
• W2150142981 cites W2155733918 @default.
• W2150142981 cites W2159256684 @default.
• W2150142981 doi "https://doi.org/10.1039/c003480k" @default.
• W2150142981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20505881" @default.
• W2150142981 hasPublicationYear "2010" @default.
• W2150142981 type Work @default.
• W2150142981 sameAs 2150142981 @default.
• W2150142981 citedByCount "4" @default.
• W2150142981 countsByYear W21501429812013 @default.
• W2150142981 crossrefType "journal-article" @default.
• W2150142981 hasAuthorship W2150142981A5058844502 @default.
• W2150142981 hasAuthorship W2150142981A5072298561 @default.
• W2150142981 hasConcept C104317684 @default.
• W2150142981 hasConcept C114614502 @default.
• W2150142981 hasConcept C119599485 @default.
• W2150142981 hasConcept C121332964 @default.
• W2150142981 hasConcept C127413603 @default.
• W2150142981 hasConcept C133731056 @default.
• W2150142981 hasConcept C134146338 @default.
• W2150142981 hasConcept C145420912 @default.
• W2150142981 hasConcept C154945302 @default.
• W2150142981 hasConcept C165801399 @default.
• W2150142981 hasConcept C184670325 @default.
• W2150142981 hasConcept C184720557 @default.
• W2150142981 hasConcept C186060115 @default.
• W2150142981 hasConcept C186886427 @default.
• W2150142981 hasConcept C191908910 @default.
• W2150142981 hasConcept C2775924081 @default.
• W2150142981 hasConcept C3017962763 @default.
• W2150142981 hasConcept C3018651601 @default.
• W2150142981 hasConcept C33923547 @default.
• W2150142981 hasConcept C38652104 @default.
• W2150142981 hasConcept C41008148 @default.
• W2150142981 hasConcept C47446073 @default.
• W2150142981 hasConcept C48207687 @default.
• W2150142981 hasConcept C54355233 @default.
• W2150142981 hasConcept C60644358 @default.
• W2150142981 hasConcept C62520636 @default.
• W2150142981 hasConcept C63479239 @default.
• W2150142981 hasConcept C6929976 @default.
• W2150142981 hasConcept C86803240 @default.
• W2150142981 hasConcept C88045685 @default.
• W2150142981 hasConcept C93586867 @default.
• W2150142981 hasConceptScore W2150142981C104317684 @default.
• W2150142981 hasConceptScore W2150142981C114614502 @default.
• W2150142981 hasConceptScore W2150142981C119599485 @default.
• W2150142981 hasConceptScore W2150142981C121332964 @default.
• W2150142981 hasConceptScore W2150142981C127413603 @default.
• W2150142981 hasConceptScore W2150142981C133731056 @default.
• W2150142981 hasConceptScore W2150142981C134146338 @default.
• W2150142981 hasConceptScore W2150142981C145420912 @default.
• W2150142981 hasConceptScore W2150142981C154945302 @default.
• W2150142981 hasConceptScore W2150142981C165801399 @default.
• W2150142981 hasConceptScore W2150142981C184670325 @default.
• W2150142981 hasConceptScore W2150142981C184720557 @default.
• W2150142981 hasConceptScore W2150142981C186060115 @default.
• W2150142981 hasConceptScore W2150142981C186886427 @default.
• W2150142981 hasConceptScore W2150142981C191908910 @default.
• W2150142981 hasConceptScore W2150142981C2775924081 @default.

• next