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• W2150171130 endingPage "1665" @default.
• W2150171130 startingPage "1659" @default.
• W2150171130 abstract "Abstract The TCR repertoire of CD8+ T cells specific for Moloney murine leukemia virus (M-MuLV)-associated Ags has been investigated in vitro and in vivo. Analysis of a large panel of established CD8+CTL clones specific for M-MuLV indicated an overwhelming bias for Vβ4 in BALB/c mice and for Vβ5.2 in C57BL/6 mice. These Vβ biases were already detectable in mixed lymphocyte:tumor cell cultures established from virus-immune spleen cells. Furthermore, direct ex vivo analysis of PBL from BALB/c or C57BL/6 mice immunized with syngeneic M-MuLV-infected tumor cells revealed a dramatic increase in CD8+ cells expressing Vβ4 or Vβ5.2, respectively. M-MuLV-specific CD8+ cells with an activated (CD62L−) phenotype persisted in blood of immunized mice for at least 2 mo, and exhibited decreased TCR and CD8 levels compared with their naive counterparts. In C57BL/6 mice, most M-MuLV-specific CD8+CTL clones and immune PBL coexpressed Vα3.2 in association with Vβ5.2. Moreover, these Vβ5.2+Vα3.2+ cells were shown to recognize the recently described H-2Db-restricted epitope (CCLCLTVFL) encoded in the leader sequence of the M-MuLV gag polyprotein. Collectively, our data demonstrate a highly restricted TCR repertoire in the CD8+ T cell response to M-MuLV-associated Ags in vivo, and suggest the potential utility of flow-microfluorometric analysis of Vβ and Vα expression in the diagnosis and monitoring of viral infections." @default.
• W2150171130 created "2016-06-24" @default.
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• W2150171130 date "1998-02-15" @default.
• W2150171130 modified "2023-09-26" @default.
• W2150171130 title "Flow-Microfluorometric Monitoring of Oligoclonal CD8+ T Cell Responses to an Immunodominant Moloney Leukemia Virus-Encoded Epitope In Vivo" @default.
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• W2150171130 doi "https://doi.org/10.4049/jimmunol.160.4.1659" @default.
• W2150171130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9469422" @default.
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