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- W2150172090 abstract "The long-term depression (LTD) of parallel fiber (PF) synapses onto Purkinje cells plays a central role in motor learning. Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR1, require postsynaptic calcium increases, are synapse specific, and have a similar dependence on the associative activation of PF and climbing fiber synapses. These similarities suggest that endocannabinoid release could account for many features of cerebellar LTD. Here we show that LTD induction is blocked by a cannabinoid receptor (CB1R) antagonist, by inhibiting the synthesis of the endocannabinoid 2-arachidonyl glycerol (2-AG), and is absent in mice lacking the CB1R. Although CB1Rs are prominently expressed presynaptically at PF synapses, LTD is expressed postsynaptically. In contrast, a previously described transient form of inhibition mediated by endocannabinoids is expressed presynaptically. This indicates that Purkinje cells release 2-AG that activates CB1Rs to both transiently inhibit release and induce a postsynaptic form of LTD." @default.
- W2150172090 created "2016-06-24" @default.
- W2150172090 creator A5039350842 @default.
- W2150172090 creator A5053791142 @default.
- W2150172090 date "2005-11-01" @default.
- W2150172090 modified "2023-09-24" @default.
- W2150172090 title "Endocannabinoids Control the Induction of Cerebellar LTD" @default.
- W2150172090 cites W1550267154 @default.
- W2150172090 cites W1554606633 @default.
- W2150172090 cites W1571745125 @default.
- W2150172090 cites W1591647183 @default.
- W2150172090 cites W1654380405 @default.
- W2150172090 cites W1774176118 @default.
- W2150172090 cites W1836729582 @default.
- W2150172090 cites W1845377771 @default.
- W2150172090 cites W1858802571 @default.
- W2150172090 cites W1968083340 @default.
- W2150172090 cites W1968911801 @default.
- W2150172090 cites W1972392931 @default.
- W2150172090 cites W1973560063 @default.
- W2150172090 cites W1973653064 @default.
- W2150172090 cites W1976709166 @default.
- W2150172090 cites W1980990150 @default.
- W2150172090 cites W1982291289 @default.
- W2150172090 cites W1982604009 @default.
- W2150172090 cites W1983825733 @default.
- W2150172090 cites W1986155820 @default.
- W2150172090 cites W1988601767 @default.
- W2150172090 cites W1989756472 @default.
- W2150172090 cites W1990676315 @default.
- W2150172090 cites W1991218496 @default.
- W2150172090 cites W1992088218 @default.
- W2150172090 cites W1993109240 @default.
- W2150172090 cites W1994207775 @default.
- W2150172090 cites W1995892478 @default.
- W2150172090 cites W1997727729 @default.
- W2150172090 cites W1998141662 @default.
- W2150172090 cites W1998747207 @default.
- W2150172090 cites W1998911334 @default.
- W2150172090 cites W1999400614 @default.
- W2150172090 cites W1999808927 @default.
- W2150172090 cites W2000851970 @default.
- W2150172090 cites W2000853989 @default.
- W2150172090 cites W2002151621 @default.
- W2150172090 cites W2010753031 @default.
- W2150172090 cites W2011223687 @default.
- W2150172090 cites W2013961851 @default.
- W2150172090 cites W2018485571 @default.
- W2150172090 cites W2018759189 @default.
- W2150172090 cites W2027565428 @default.
- W2150172090 cites W2028985118 @default.
- W2150172090 cites W2029638208 @default.
- W2150172090 cites W2034696845 @default.
- W2150172090 cites W2041147278 @default.
- W2150172090 cites W2042813287 @default.
- W2150172090 cites W2051827768 @default.
- W2150172090 cites W2056188558 @default.
- W2150172090 cites W2057012057 @default.
- W2150172090 cites W2057605801 @default.
- W2150172090 cites W2060694966 @default.
- W2150172090 cites W2064128689 @default.
- W2150172090 cites W2065542456 @default.
- W2150172090 cites W2067050090 @default.
- W2150172090 cites W2075894678 @default.
- W2150172090 cites W2079332926 @default.
- W2150172090 cites W2079785767 @default.
- W2150172090 cites W2081620736 @default.
- W2150172090 cites W2085327871 @default.
- W2150172090 cites W2090765114 @default.
- W2150172090 cites W2090935893 @default.
- W2150172090 cites W2092917982 @default.
- W2150172090 cites W2097942881 @default.
- W2150172090 cites W2101347364 @default.
- W2150172090 cites W2104321133 @default.
- W2150172090 cites W2108072597 @default.
- W2150172090 cites W2112465764 @default.
- W2150172090 cites W2112927743 @default.
- W2150172090 cites W2122461440 @default.
- W2150172090 cites W2123179212 @default.
- W2150172090 cites W2126766019 @default.
- W2150172090 cites W2131856835 @default.
- W2150172090 cites W2138810055 @default.
- W2150172090 cites W2139191974 @default.
- W2150172090 cites W2142061594 @default.
- W2150172090 cites W2143470223 @default.
- W2150172090 cites W2146732533 @default.
- W2150172090 cites W2147929015 @default.
- W2150172090 cites W2155848526 @default.
- W2150172090 cites W2156715387 @default.
- W2150172090 cites W2166806732 @default.
- W2150172090 cites W2171584675 @default.
- W2150172090 cites W2187037705 @default.
- W2150172090 doi "https://doi.org/10.1016/j.neuron.2005.09.020" @default.
- W2150172090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16301180" @default.
- W2150172090 hasPublicationYear "2005" @default.
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