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- W2150172657 abstract "The effect of fasting and glucose-infusion on valproate (VPA) disposition was investigated to determine the involvement of endogenous fatty acid (FA) beta-oxidation in the metabolism of VPA. Fifteen healthy volunteers received multiple oral doses of VPA to achieve steady state under both conditions. Depressed plasma FA concentrations in the glucose-infused state (median 51%, p less than 0.0001) were associated with lower unbound plasma VPA fractions (median 17%, p less than 0.0001). Unbound plasma VPA concentrations were notably lower in the glucose-infused state due to significantly higher (median 41%, p less than 0.0001) metabolic clearance, beta-oxidative metabolite formation clearance, representing the largest urinary dose fraction recovered, was significantly higher (median 60%, p less than 0.004) in the glucose-infused state. This finding is consistent with competition between endogenous FA and VPA for the enzymes of beta-oxidation modulated by conditions which affect FA mobilization to the site of catabolism." @default.
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- W2150172657 date "1989-12-01" @default.
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- W2150172657 title "β-Oxidation of Valproic Acid.." @default.
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- W2150172657 doi "https://doi.org/10.1111/j.1528-1157.1989.tb05338.x" @default.
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