FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150179550> ?p ?o ?g. }

• W2150179550 endingPage "3" @default.
• W2150179550 startingPage "2490" @default.
• W2150179550 abstract "This study investigated the in vitro and in vivo radiation response of tumor cells transfected with human manganese superoxide dismutase (MnSOD) cDNA. A major objective was to test the potential tumor suppressive effect of MnSOD in vivo. Tumor cells studied were an in vitro line derived from a murine spontaneous fibrosarcoma, FSa-II, which expressed an undetectable MnSOD activity. These cells were transfected with pSV2-NEO plasmid (NEO line) or cotransfected with MnSOD plasmid plus pSV2-NEO plasmid (SOD lines) as described previously. The cell lines used were SOD-L and SOD-H, which expressed, respectively, low and high MnSOD activities after transfection, and NEO and parental FSa-II controls. Both SOD-L and SOD-H cell lines were slightly more resistant to ionizing radiation than were the two control cell lines when irradiated in vitro in the presence of oxygen. The dose-modifying factors calculated at the survival level of 0.01 were 1.13 and 1.15 for the SOD-L and SOD-H cells, respectively. To investigate potential tumor suppressive effects, animal tumors of 4 mm diameter were irradiated in vivo under hypoxic conditions, and the radiation dose to control one-half of the irradiated tumors (TCD50) was determined for each tumor. The TCD50S obtained on the basis of the tumor control rate in 120 days after irradiation were substantially lower for the SOD-H and SOD-L tumors compared to the NEO tumors. They were 22.9, 28.6, and 47.5 Gy for SOD-H, SOD-L and NEO tumors, respectively. To analyze these data, survival curves were obtained for hypoxic cells by irradiating NEO and SOD-H tumors under hypoxic conditions in vivo and assaying in vitro. Analysis of these curves suggests that the decrease in the TCD50S of SOD tumors is attributable to the reduced tumorigenicity in these tumors. The hypoxic cell survival curves also showed that SOD did not protect cells from radiation in the absence of oxygen. Electron microscopy showed no morphological differences between these cells. These results suggest that the fraction of tumorigenic cells could be reduced by expression of MnSOD, resulting in a substantial decrease in the TCD50." @default.
• W2150179550 created "2016-06-24" @default.
• W2150179550 creator A5005401059 @default.
• W2150179550 creator A5007869873 @default.
• W2150179550 creator A5010328833 @default.
• W2150179550 creator A5063851579 @default.
• W2150179550 creator A5088219663 @default.
• W2150179550 date "1995-06-15" @default.
• W2150179550 modified "2023-09-27" @default.
• W2150179550 title "Expression of manganese superoxide dismutase reduces tumor control radiation dose: gene-radiotherapy." @default.
• W2150179550 cites W1528329063 @default.
• W2150179550 cites W1857597751 @default.
• W2150179550 cites W1974133167 @default.
• W2150179550 cites W2000237014 @default.
• W2150179550 cites W2037761888 @default.
• W2150179550 cites W2060720981 @default.
• W2150179550 cites W2070712167 @default.
• W2150179550 cites W2075561384 @default.
• W2150179550 cites W2077934188 @default.
• W2150179550 cites W2089913301 @default.
• W2150179550 cites W2109717482 @default.
• W2150179550 cites W2121774612 @default.
• W2150179550 cites W2148257009 @default.
• W2150179550 cites W2150800664 @default.
• W2150179550 cites W2156112875 @default.
• W2150179550 cites W2162695832 @default.
• W2150179550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7780953" @default.
• W2150179550 hasPublicationYear "1995" @default.
• W2150179550 type Work @default.
• W2150179550 sameAs 2150179550 @default.
• W2150179550 citedByCount "20" @default.
• W2150179550 countsByYear W21501795502012 @default.
• W2150179550 countsByYear W21501795502017 @default.
• W2150179550 countsByYear W21501795502018 @default.
• W2150179550 countsByYear W21501795502020 @default.
• W2150179550 crossrefType "journal-article" @default.
• W2150179550 hasAuthorship W2150179550A5005401059 @default.
• W2150179550 hasAuthorship W2150179550A5007869873 @default.
• W2150179550 hasAuthorship W2150179550A5010328833 @default.
• W2150179550 hasAuthorship W2150179550A5063851579 @default.
• W2150179550 hasAuthorship W2150179550A5088219663 @default.
• W2150179550 hasConcept C153911025 @default.
• W2150179550 hasConcept C181199279 @default.
• W2150179550 hasConcept C185592680 @default.
• W2150179550 hasConcept C202751555 @default.
• W2150179550 hasConcept C207001950 @default.
• W2150179550 hasConcept C2775838275 @default.
• W2150179550 hasConcept C2776495794 @default.
• W2150179550 hasConcept C502942594 @default.
• W2150179550 hasConcept C54009773 @default.
• W2150179550 hasConcept C54355233 @default.
• W2150179550 hasConcept C55493867 @default.
• W2150179550 hasConcept C81885089 @default.
• W2150179550 hasConcept C86803240 @default.
• W2150179550 hasConceptScore W2150179550C153911025 @default.
• W2150179550 hasConceptScore W2150179550C181199279 @default.
• W2150179550 hasConceptScore W2150179550C185592680 @default.
• W2150179550 hasConceptScore W2150179550C202751555 @default.
• W2150179550 hasConceptScore W2150179550C207001950 @default.
• W2150179550 hasConceptScore W2150179550C2775838275 @default.
• W2150179550 hasConceptScore W2150179550C2776495794 @default.
• W2150179550 hasConceptScore W2150179550C502942594 @default.
• W2150179550 hasConceptScore W2150179550C54009773 @default.
• W2150179550 hasConceptScore W2150179550C54355233 @default.
• W2150179550 hasConceptScore W2150179550C55493867 @default.
• W2150179550 hasConceptScore W2150179550C81885089 @default.
• W2150179550 hasConceptScore W2150179550C86803240 @default.
• W2150179550 hasIssue "12" @default.
• W2150179550 hasLocation W21501795501 @default.
• W2150179550 hasOpenAccess W2150179550 @default.
• W2150179550 hasPrimaryLocation W21501795501 @default.
• W2150179550 hasRelatedWork W182506760 @default.
• W2150179550 hasRelatedWork W1972094566 @default.
• W2150179550 hasRelatedWork W1982196284 @default.
• W2150179550 hasRelatedWork W2023600059 @default.
• W2150179550 hasRelatedWork W2074915237 @default.
• W2150179550 hasRelatedWork W2090906296 @default.
• W2150179550 hasRelatedWork W2368550090 @default.
• W2150179550 hasRelatedWork W2419600548 @default.
• W2150179550 hasRelatedWork W3143332363 @default.
• W2150179550 hasRelatedWork W3149144397 @default.
• W2150179550 hasVolume "55" @default.
• W2150179550 isParatext "false" @default.
• W2150179550 isRetracted "false" @default.
• W2150179550 magId "2150179550" @default.
• W2150179550 workType "article" @default.