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• W2150230666 startingPage "E1047" @default.
• W2150230666 abstract "Obesity and metabolic syndrome are associated with an increased risk for several diabetic complications, including diabetic nephropathy and chronic kidney diseases. Oxidative stress and mitochondrial dysfunction are often proposed mechanisms in various organs in obesity models, but limited data are available on the kidney. Here, we fed a lard-based high-fat diet to mice to investigate structural changes, cellular and subcellular oxidative stress and redox status, and mitochondrial biogenesis and function in the kidney. The diet induced characteristic changes, including glomerular hypertrophy, fibrosis, and interstitial scarring, which were accompanied by a proinflammatory transition. We demonstrate evidence for oxidative stress in the kidney through 3-nitrotyrosine and protein radical formation on high-fat diet with a contribution from iNOS and NOX-4 as well as increased generation of mitochondrial oxidants on carbohydrate- and lipid-based substrates. The increased H 2 O 2 emission in the mitochondria suggests altered redox balance and mitochondrial ROS generation, contributing to the overall oxidative stress. No major derailments were observed in respiratory function or biogenesis, indicating preserved and initially improved bioenergetic parameters and energy production. We suggest that, regardless of the oxidative stress events, the kidney developed an adaptation to maintain normal respiratory function as a possible response to an increased lipid overload. These findings provide new insights into the complex role of oxidative stress and mitochondrial redox status in the pathogenesis of the kidney in obesity and indicate that early oxidative stress-related changes, but not mitochondrial bioenergetic dysfunction, may contribute to the pathogenesis and development of obesity-linked chronic kidney diseases." @default.
• W2150230666 created "2016-06-24" @default.
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• W2150230666 date "2011-06-01" @default.
• W2150230666 modified "2023-09-27" @default.
• W2150230666 title "High-fat diet induces an initial adaptation of mitochondrial bioenergetics in the kidney despite evident oxidative stress and mitochondrial ROS production" @default.
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• W2150230666 doi "https://doi.org/10.1152/ajpendo.00666.2010" @default.
• W2150230666 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118596" @default.
• W2150230666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21386058" @default.
• W2150230666 hasPublicationYear "2011" @default.
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