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- W2150238045 abstract "<b>Background:</b> Single measurements of peak oxygen uptake (V˙o<sub>2</sub>) have been shown to predict mortality in patients with cystic fibrosis (CF) although no longitudinal study of serial measurements has been reported in children. A study was undertaken to determine whether the initial, final, or the rate of fall of forced expiratory volume in 1 second (FEV<sub>1</sub>) or peak V˙o<sub>2</sub> was a better predictor of mortality. <b>Methods:</b> Twenty eight children aged 8–17 years with CF performed annual pulmonary function and maximal exercise tests over a 5 year period to determine FEV<sub>1</sub> and peak V˙o<sub>2</sub>, magnitude of their change over time, and survival over the subsequent 7–8 years. Analysis was done using Kaplan-Meier curves and Cox proportional hazard model. <b>Results:</b> Peak V˙o<sub>2</sub> fell during the observation period in 70% of the patients, with a mean annual decline of 2.1 ml/min/kg. Initial peak V˙o<sub>2</sub> was not predictive of mortality but rate of decline and final peak V˙o<sub>2</sub> of the series were significant predictors. Patients with peak V˙o<sub>2</sub> less than 32 ml/min/kg exhibited a dramatic increase in mortality, in contrast to those whose peak V˙o<sub>2</sub> exceeded 45 ml/min/kg, none of whom died. The first, last, and rate of decline in FEV<sub>1</sub> over time were all significant predictors of mortality. <b>Conclusions:</b> Higher peak V˙o<sub>2</sub> is a marker for longer survival in CF patients." @default.
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- W2150238045 date "2005-01-01" @default.
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- W2150238045 title "Peak oxygen uptake and mortality in children with cystic fibrosis" @default.
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- W2150238045 doi "https://doi.org/10.1136/thx.2003.008102" @default.
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