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• W2150244019 abstract "N-3 polyunsaturated fatty acids (n-3 PUFA) affect inflammatory processes. This study evaluated the effects of dietary supplementation with fish oil on hepatic ischemia-reperfusion (IR) injury in the rat. Parameters of liver injury (serum transaminases and histology) and oxidative stress (serum 8-isoprostanes and hepatic GSH and GSSG), were correlated with NF-κB DNA binding and FA composition and inflammatory cytokine release. N-3 PUFA supplementation significantly increased liver n-3 PUFA content and decreased n-6/n-3 PUFA ratios. IR significantly modified liver histology and enhanced serum transaminases, 8-isoprotanes and inflammatory cytokines, with net reduction in liver GSH levels and net increment in those of GSSG. Early increase (3 h) and late reduction (20 h) in NF-κB activity was induced. All IR-induced changes were normalized by n-3 PUFA supplementation. In conclusion, prevention of liver IR-injury was achieved by n-3 PUFA supplementation, with suppression of oxidative stress and recovery of pro-inflammatory cytokine homeostasis and NF-κB functionality lost during IR." @default.
• W2150244019 created "2016-06-24" @default.
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• W2150244019 date "2010-06-09" @default.
• W2150244019 modified "2023-10-03" @default.
• W2150244019 title "Protection against<i>in vivo</i>liver ischemia-reperfusion injury by<i>n-3</i>long-chain polyunsaturated fatty acids in the rat" @default.
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• W2150244019 doi "https://doi.org/10.3109/10715762.2010.485995" @default.
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