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- W2150269711 abstract "The heat-shock response is characterized by the expression of a set of classical heat-shock genes, and is regulated by heat-shock transcription factor 1 (HSF1) in mammals. However, comprehensive analyses of gene expression have revealed very large numbers of inducible genes in cells exposed to heat shock. It is believed that HSF1 is required for the heat-inducible expression of these genes although HSF2 and HSF4 modulate some of the gene expression. Here, we identified a novel mouse HSF3 (mHSF3) translocated into the nucleus during heat shock. However, mHSF3 did not activate classical heat-shock genes such as Hsp70. Remarkably, overexpression of mHSF3 restored the expression of nonclassical heat-shock genes such as PDZK3 and PROM2 in HSF1-null mouse embryonic fibroblasts (MEFs). Although down-regulation of mHSF3 expression had no effect on gene expression or cell survival in wild-type MEF cells, it abolished the moderate expression of PDZK3 mRNA and reduced cell survival in HSF1-null MEF cells during heat shock. We propose that mHSF3 represents a unique HSF that has the potential to activate only nonclassical heat-shock genes to protect cells from detrimental stresses." @default.
- W2150269711 created "2016-06-24" @default.
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- W2150269711 date "2010-01-01" @default.
- W2150269711 modified "2023-09-27" @default.
- W2150269711 title "A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock" @default.
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- W2150269711 doi "https://doi.org/10.1091/mbc.e09-07-0639" @default.
- W2150269711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2801703" @default.
- W2150269711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19864465" @default.
- W2150269711 hasPublicationYear "2010" @default.
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