FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150274510> ?p ?o ?g. }

• W2150274510 endingPage "125" @default.
• W2150274510 startingPage "116" @default.
• W2150274510 abstract "ObjectivesPlant-derived natural substances, such as capsaicin, with potent antiproliferative activity against cancer cells in vitro are considered to be promising nutraceuticals in anticancer therapy. Nevertheless, the limited systemic bioavailability of phytochemicals may raise questions regarding the physiological relevance of their phytochemical effects in vivo. Thus, the search for novel phytochemical-based substances with more efficient anticancer action is needed.MethodsIn the present study, a capsaicin analogue, namely, capsaicin epoxide, was synthesized, and its cytotoxic potential against cancer cells was evaluated and compared to that of capsaicin through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and multi-caspase assays. The abilities of capsaicin and capsaicin epoxide to induce oxidative stress were estimated using redox-sensitive fluorogenic probes: 2′,7′-dichlorodihydrofluorescein diacetate (H2DCF-DA) and dihydroethidium.ResultsThe structure and purity of the synthesized product were confirmed by nuclear magnetic resonance spectroscopy, electrospray ionization mass spectrometry, and gas chromatography. Normal human dermal fibroblasts were not susceptible to treatment with the agent, whereas a cancer cell type-specific response was observed. Human breast carcinoma cells were found to be the most sensitive to capsaicin epoxide treatment compared with capsaicin treatment, and the action of capsaicin epoxide was oxidant based.DiscussionOur data indicate that the antiproliferative activity of capsaicin epoxide is potentiated in vitro, when used at much lower concentrations compared with capsaicin at similar concentrations. Thus, the findings of this study may have implications for phytochemical-based anticancer drug development." @default.
• W2150274510 created "2016-06-24" @default.
• W2150274510 creator A5002514020 @default.
• W2150274510 creator A5003129718 @default.
• W2150274510 creator A5030327962 @default.
• W2150274510 creator A5066637400 @default.
• W2150274510 creator A5037054197 @default.
• W2150274510 date "2014-11-08" @default.
• W2150274510 modified "2023-10-13" @default.
• W2150274510 title "Oxidant-based anticancer activity of a novel synthetic analogue of capsaicin, capsaicin epoxide" @default.
• W2150274510 cites W130034013 @default.
• W2150274510 cites W1968453608 @default.
• W2150274510 cites W1976194786 @default.
• W2150274510 cites W1980077962 @default.
• W2150274510 cites W1982515695 @default.
• W2150274510 cites W1985800268 @default.
• W2150274510 cites W1987212108 @default.
• W2150274510 cites W1988003373 @default.
• W2150274510 cites W1988177134 @default.
• W2150274510 cites W1994033789 @default.
• W2150274510 cites W2021516892 @default.
• W2150274510 cites W2024667401 @default.
• W2150274510 cites W2037871169 @default.
• W2150274510 cites W2048595517 @default.
• W2150274510 cites W2048775455 @default.
• W2150274510 cites W2052578156 @default.
• W2150274510 cites W2058246580 @default.
• W2150274510 cites W2073199558 @default.
• W2150274510 cites W2091469486 @default.
• W2150274510 cites W2096200847 @default.
• W2150274510 cites W2102962600 @default.
• W2150274510 cites W2107204084 @default.
• W2150274510 cites W2112272457 @default.
• W2150274510 cites W2114918609 @default.
• W2150274510 cites W2130420031 @default.
• W2150274510 cites W2136102785 @default.
• W2150274510 cites W2154754127 @default.
• W2150274510 cites W2160129975 @default.
• W2150274510 cites W2166531047 @default.
• W2150274510 cites W2169238639 @default.
• W2150274510 cites W2170698646 @default.
• W2150274510 cites W2318949538 @default.
• W2150274510 cites W2333010170 @default.
• W2150274510 cites W2410095645 @default.
• W2150274510 doi "https://doi.org/10.1179/1351000214y.0000000113" @default.
• W2150274510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6837654" @default.
• W2150274510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25382686" @default.
• W2150274510 hasPublicationYear "2014" @default.
• W2150274510 type Work @default.
• W2150274510 sameAs 2150274510 @default.
• W2150274510 citedByCount "22" @default.
• W2150274510 countsByYear W21502745102016 @default.
• W2150274510 countsByYear W21502745102017 @default.
• W2150274510 countsByYear W21502745102018 @default.
• W2150274510 countsByYear W21502745102019 @default.
• W2150274510 countsByYear W21502745102020 @default.
• W2150274510 countsByYear W21502745102021 @default.
• W2150274510 countsByYear W21502745102022 @default.
• W2150274510 countsByYear W21502745102023 @default.
• W2150274510 crossrefType "journal-article" @default.
• W2150274510 hasAuthorship W2150274510A5002514020 @default.
• W2150274510 hasAuthorship W2150274510A5003129718 @default.
• W2150274510 hasAuthorship W2150274510A5030327962 @default.
• W2150274510 hasAuthorship W2150274510A5037054197 @default.
• W2150274510 hasAuthorship W2150274510A5066637400 @default.
• W2150274510 hasBestOaLocation W21502745102 @default.
• W2150274510 hasConcept C170493617 @default.
• W2150274510 hasConcept C185592680 @default.
• W2150274510 hasConcept C195475562 @default.
• W2150274510 hasConcept C2776151105 @default.
• W2150274510 hasConcept C2780051329 @default.
• W2150274510 hasConcept C55493867 @default.
• W2150274510 hasConcept C71924100 @default.
• W2150274510 hasConcept C98274493 @default.
• W2150274510 hasConceptScore W2150274510C170493617 @default.
• W2150274510 hasConceptScore W2150274510C185592680 @default.
• W2150274510 hasConceptScore W2150274510C195475562 @default.
• W2150274510 hasConceptScore W2150274510C2776151105 @default.
• W2150274510 hasConceptScore W2150274510C2780051329 @default.
• W2150274510 hasConceptScore W2150274510C55493867 @default.
• W2150274510 hasConceptScore W2150274510C71924100 @default.
• W2150274510 hasConceptScore W2150274510C98274493 @default.
• W2150274510 hasIssue "3" @default.
• W2150274510 hasLocation W21502745101 @default.
• W2150274510 hasLocation W21502745102 @default.
• W2150274510 hasLocation W21502745103 @default.
• W2150274510 hasLocation W21502745104 @default.
• W2150274510 hasOpenAccess W2150274510 @default.
• W2150274510 hasPrimaryLocation W21502745101 @default.
• W2150274510 hasRelatedWork W1525173858 @default.
• W2150274510 hasRelatedWork W1925258783 @default.
• W2150274510 hasRelatedWork W2098591746 @default.
• W2150274510 hasRelatedWork W2186086384 @default.
• W2150274510 hasRelatedWork W2214277799 @default.
• W2150274510 hasRelatedWork W2271392077 @default.
• W2150274510 hasRelatedWork W3208795098 @default.
• W2150274510 hasRelatedWork W4322617629 @default.
• W2150274510 hasRelatedWork W4386696306 @default.

• next