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- W2150291254 abstract "We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3–6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events." @default.
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- W2150291254 date "2010-10-01" @default.
- W2150291254 modified "2023-10-17" @default.
- W2150291254 title "Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study" @default.
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- W2150291254 doi "https://doi.org/10.1016/j.jneuroim.2010.07.013" @default.
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