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- W2150314587 endingPage "445" @default.
- W2150314587 startingPage "415" @default.
- W2150314587 abstract "Dopamine (DA) is the prevalent catecholaminergic neurotransmitter in the brain and dopaminergic neurons are mainly located in the substantia nigra (SN), the ventral tegmental area (VTA), and arcuate nuclei. They constitute at least three important dopaminergic pathways: the nigro-striatal, the mesocortical-mesolimbic, and the tubero-infundibular system, which are responsible for locomotor movement, motivation and reward, and secretion of pituitary gland hormones, respectively (,). The dysfunction of these systems can lead to neurological, psychological and endocrinological diseases like, e.g., Parkinson’s disease (PD), attention deficit hyperactivity disorder (ADHD), and prolactinoma (). There is increasing evidence that DA, besides acting as a neurotransmitter, can become neurotoxic at high concentrations or in an oxidative environment. Especially in idiopathic PD, even though the SN is not the only affected region in the brain, the main pathological hallmark is the progressive degeneration of the neuromelanin-containing dopaminergic neurons in the SN pars compacta (SNpc) causing the cardinal symptoms of tremor, rigidity, and bradykinesia. It is believed that the interplay between the high DA content and a local pro-oxidative environment in the SN mutually promote the increase of oxidative stress and thus the degeneration of dopaminergic neurons." @default.
- W2150314587 created "2016-06-24" @default.
- W2150314587 creator A5055963680 @default.
- W2150314587 creator A5069476421 @default.
- W2150314587 date "2005-01-01" @default.
- W2150314587 modified "2023-09-27" @default.
- W2150314587 title "Dopamine and Neurodegeneration" @default.
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