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• W2150352008 abstract "Lung transplant is a treatment modality for patients with end stage lung disease. Bronchiolitis obliterans syndrome (BOS) is the number one cause of morbidity and mortality in patients the first year after lung transplant. There are many risk factors which have been identified to increase the risk of BOS including acute rejection, lymphocytic bronchitis, medication non-compliance, bacterial or viral infections, older donor age, extended ischemic time, donor antigen-specific reactivity, human leukocyte antigen (HLA) mismatch, underlying disease and gastroesophageal reflux disease (GERD). Advanced practice nurses can help in the primary prevention of BOS through the assessment and treatment of pre-transplant patients with GERD. A descriptive study using retrospective chart reviews of lung transplant recipients was conducted to evaluate the relationship between pre-transplant GERD and post-transplant BOS. The incidence of pre-transplant GERD was 39%. The incidence ofBOS at year one was 17% and at year two was 32%. There was not a significant relationship between pre-transplant GERD and post-transplant BOS. CHAPTER ONE Introduction Over 1700 transplants are performed world wide every year for select end stage lung diseases (Trulock et al., 2005). The most common diseases for which lung transplant is an indication are chronic obstructive lung disease, idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), pulmonary hypertension, and Eisenmenger syndromes. Less common indications for lung transplant include bronchiectasis, sarcoidosis, and lymphangioleiomyomatosis (LAM) and pulmonary Langerhans cell histiocytosis (Trulock et al., 2005). One possible complication of lung transplant is chronic rejection, more commonly known as bronchiolitis obliterans syndrome (BOS). BOS is the most common cause of death after the first year post-transplant (Trulock et al., 2005). The cause ofBOS is unclear and controversial. Gastroesophageal reflux disease (GERD) is a comorbid condition in end stage lung disease and is a suspected risk factor for the development of BOS in lung transplant recipients (D'Ovidio & Keshavjee, 2006; Trulock et al., 2005). Although there have been multiple studies that have looked at the role of GERD and allograft dysfunction, further research examining GERD and its association with BOS is warranted to optimize prevention and treatment options." @default.
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• W2150352008 date "2009-01-01" @default.
• W2150352008 modified "2023-09-27" @default.
• W2150352008 title "The Relationship Between Preexisting Gastroesophageal Reflux Disease in Lung Transplant Recipients and the Development of Post-Transplant Bronciolitis Obliterans" @default.
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