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• W2150367032 abstract "When the host encounters a pathogen, the ensuing immune response involves a complex set of cellular responses distributed across many different types of cells. In T and B lymphocytes of the adaptive immune system, these responses include irreversible differentiation events that generate functionally specialized subpopulations of cells (1). Understanding how pathogens and vaccines influence the number, type, and efficacy of specific differentiation states in the T-cell compartment is a major goal in immunology. The study by Han et al. in PNAS (2) interrogates the functional response of individual T cells over time using a nanofluidic platform. Their experiments reveal that the sequence of cytokines released over time by individual activated T cells is highly diverse but tightly programmed. Their work suggests that understanding the complexity of the T-cell response may not only be a matter of cataloging the possible phenotypes present in a cross-section of the T-cell population but will also need to involve understanding how those functions change over time." @default.
• W2150367032 created "2016-06-24" @default.
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• W2150367032 date "2012-01-20" @default.
• W2150367032 modified "2023-09-23" @default.
• W2150367032 title "Travels in time: Assessing the functional complexity of T cells" @default.
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• W2150367032 doi "https://doi.org/10.1073/pnas.1119856109" @default.
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