FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150368001> ?p ?o ?g. }

• W2150368001 endingPage "13014" @default.
• W2150368001 startingPage "13001" @default.
• W2150368001 abstract "ABSTRACT Hepatitis C virus (HCV) replication appears to be restricted to the human hepatoma cell line Huh-7, indicating that a favorable cellular environment exists within these cells. Although adaptive mutations in the HCV nonstructural proteins typically enhance the replicative capacity of subgenomic replicons in Huh-7 cells, replication can only be detected in a subpopulation of these cells. Here we show that self-replicating subgenomic RNA could be eliminated from Huh-7 clones by prolonged treatment with alpha interferon (IFN-α) and that a higher frequency of cured cells could support both subgenomic and full-length HCV replication. The increased permissiveness of one of the cured cell lines allowed us to readily detect HCV RNA and antigens early after RNA transfection, eliminating the need for selection of replication-positive cells. We also demonstrate that a single amino acid substitution in NS5A is sufficient for establishing HCV replication in a majority of cured cells and that the major phosphate acceptor site of subtype 1b NS5A is not essential for HCV replication." @default.
• W2150368001 created "2016-06-24" @default.
• W2150368001 creator A5019683467 @default.
• W2150368001 creator A5028520879 @default.
• W2150368001 creator A5037749325 @default.
• W2150368001 date "2002-12-15" @default.
• W2150368001 modified "2023-10-10" @default.
• W2150368001 title "Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication" @default.
• W2150368001 cites W1493432185 @default.
• W2150368001 cites W1577743463 @default.
• W2150368001 cites W1914884504 @default.
• W2150368001 cites W1956249391 @default.
• W2150368001 cites W1978952362 @default.
• W2150368001 cites W2004811534 @default.
• W2150368001 cites W2020004919 @default.
• W2150368001 cites W2032451726 @default.
• W2150368001 cites W2059280966 @default.
• W2150368001 cites W2064551924 @default.
• W2150368001 cites W2071056869 @default.
• W2150368001 cites W2076815050 @default.
• W2150368001 cites W2078887917 @default.
• W2150368001 cites W2091737836 @default.
• W2150368001 cites W2093137226 @default.
• W2150368001 cites W2099951913 @default.
• W2150368001 cites W2106132583 @default.
• W2150368001 cites W2106239124 @default.
• W2150368001 cites W2107085672 @default.
• W2150368001 cites W2110289105 @default.
• W2150368001 cites W2126153046 @default.
• W2150368001 cites W2127685726 @default.
• W2150368001 cites W2139287551 @default.
• W2150368001 cites W2140518449 @default.
• W2150368001 cites W2143153134 @default.
• W2150368001 cites W2151898297 @default.
• W2150368001 cites W2155431764 @default.
• W2150368001 cites W2160425277 @default.
• W2150368001 cites W350080822 @default.
• W2150368001 doi "https://doi.org/10.1128/jvi.76.24.13001-13014.2002" @default.
• W2150368001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/136668" @default.
• W2150368001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12438626" @default.
• W2150368001 hasPublicationYear "2002" @default.
• W2150368001 type Work @default.
• W2150368001 sameAs 2150368001 @default.
• W2150368001 citedByCount "1114" @default.
• W2150368001 countsByYear W21503680012012 @default.
• W2150368001 countsByYear W21503680012013 @default.
• W2150368001 countsByYear W21503680012014 @default.
• W2150368001 countsByYear W21503680012015 @default.
• W2150368001 countsByYear W21503680012016 @default.
• W2150368001 countsByYear W21503680012017 @default.
• W2150368001 countsByYear W21503680012018 @default.
• W2150368001 countsByYear W21503680012019 @default.
• W2150368001 countsByYear W21503680012020 @default.
• W2150368001 countsByYear W21503680012021 @default.
• W2150368001 countsByYear W21503680012022 @default.
• W2150368001 countsByYear W21503680012023 @default.
• W2150368001 crossrefType "journal-article" @default.
• W2150368001 hasAuthorship W2150368001A5019683467 @default.
• W2150368001 hasAuthorship W2150368001A5028520879 @default.
• W2150368001 hasAuthorship W2150368001A5037749325 @default.
• W2150368001 hasBestOaLocation W21503680011 @default.
• W2150368001 hasConcept C104317684 @default.
• W2150368001 hasConcept C140704245 @default.
• W2150368001 hasConcept C153911025 @default.
• W2150368001 hasConcept C159047783 @default.
• W2150368001 hasConcept C18103114 @default.
• W2150368001 hasConcept C189819185 @default.
• W2150368001 hasConcept C22744801 @default.
• W2150368001 hasConcept C2522874641 @default.
• W2150368001 hasConcept C2776178377 @default.
• W2150368001 hasConcept C2776408679 @default.
• W2150368001 hasConcept C2777103181 @default.
• W2150368001 hasConcept C2777890099 @default.
• W2150368001 hasConcept C2781463415 @default.
• W2150368001 hasConcept C54355233 @default.
• W2150368001 hasConcept C67705224 @default.
• W2150368001 hasConcept C81885089 @default.
• W2150368001 hasConcept C83100098 @default.
• W2150368001 hasConcept C86803240 @default.
• W2150368001 hasConceptScore W2150368001C104317684 @default.
• W2150368001 hasConceptScore W2150368001C140704245 @default.
• W2150368001 hasConceptScore W2150368001C153911025 @default.
• W2150368001 hasConceptScore W2150368001C159047783 @default.
• W2150368001 hasConceptScore W2150368001C18103114 @default.
• W2150368001 hasConceptScore W2150368001C189819185 @default.
• W2150368001 hasConceptScore W2150368001C22744801 @default.
• W2150368001 hasConceptScore W2150368001C2522874641 @default.
• W2150368001 hasConceptScore W2150368001C2776178377 @default.
• W2150368001 hasConceptScore W2150368001C2776408679 @default.
• W2150368001 hasConceptScore W2150368001C2777103181 @default.
• W2150368001 hasConceptScore W2150368001C2777890099 @default.
• W2150368001 hasConceptScore W2150368001C2781463415 @default.
• W2150368001 hasConceptScore W2150368001C54355233 @default.
• W2150368001 hasConceptScore W2150368001C67705224 @default.
• W2150368001 hasConceptScore W2150368001C81885089 @default.
• W2150368001 hasConceptScore W2150368001C83100098 @default.
• W2150368001 hasConceptScore W2150368001C86803240 @default.
• W2150368001 hasIssue "24" @default.

• next