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- W2150372150 abstract "Summary. Mouse two-cell embryos and blastocysts take up [3H]glutamine in vitro at a constant rate for at least 15 min, depending on the concentration of glutamine and developmental stage of the embryo. Uptake by two-cell embryos can be resolved into two saturable components. The major contributing system is Na+ independent, inhibited by alanine, methionine, 2-amino-2-norbornanecarboxylic acid (BCH) or leucine and has a Km of 3856 ± 672 μmol l−1 and Vmax of 436 ± 58 fmol per embryo per 10 min. These features are characteristics of the ubiquitous system L transporter. The second component is Na+ dependent with Km of 1064 ± 914 μmol l−1 and Vmax 107 ± 47 fmol per embryo per 10 min. Similar Vmax and inhibition of this component by glycine suggest a low reactivity with the gly-system. Blastocyst uptake of glutamine is mainly by a Na+-dependent saturable mechanism with Km of 524 ± 75 μmol l−1 and Vmax of 1264 ± 101 fmol per embryo per 10 min which is inhibited by alanine, isoleucine, leucine and BCH, features characteristic of the system B0,+. The increase in uptake capacity as a consequence of the appearance of the system B0,+ may be related to increased metabolic requirements for glutamine, in the rapidly expanding blastocyst. Keywords: glutamine transport; blastocyst; embryo; system L; system B0,+; mouse" @default.
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- W2150372150 title "Characterization of glutamine uptake in mouse two-cell embryos and blastocysts" @default.
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- W2150372150 doi "https://doi.org/10.1530/jrf.0.0950221" @default.
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