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- W2150373017 startingPage "e1000218" @default.
- W2150373017 abstract "Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus, the relative role of these receptors has not been formally examined. In this paper, we have investigated the contribution of the mannose receptor, Dectin-1, and complement receptor 3; and we have demonstrated that Dectin-1 is the main non-opsonic receptor involved in fungal uptake. However, both Dectin-1 and complement receptor 3 were found to accumulate at the site of uptake, while mannose receptor accumulated on C. albicans phagosomes at later stages. These results suggest a potential role for MR in phagosome sampling; and, accordingly, MR deficiency led to a reduction in TNF-α and MCP-1 production in response to C. albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion." @default.
- W2150373017 created "2016-06-24" @default.
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- W2150373017 creator A5060388462 @default.
- W2150373017 creator A5077276881 @default.
- W2150373017 date "2008-11-28" @default.
- W2150373017 modified "2023-10-10" @default.
- W2150373017 title "Stage-Specific Sampling by Pattern Recognition Receptors during Candida albicans Phagocytosis" @default.
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- W2150373017 doi "https://doi.org/10.1371/journal.ppat.1000218" @default.
- W2150373017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2583056" @default.
- W2150373017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19043561" @default.
- W2150373017 hasPublicationYear "2008" @default.
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