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• W2150373453 abstract "1. Glomerular filtration rate ([3H]inulin clearance) and renal plasma flow (PAH clearance) were measured in unanaesthetized Sprague-Dawley rats early in pregnancy (8-10 days) and near term (18-20 days); the results were compared with studies in virgin litter-mates. Evidence of kidney growth was sought by analysing renal dry weights as well as [14C]choline incorporation into membrane phospholipids of renal cortical slices. 2. Inulin clearances were similar early in pregnancy (pregnant 2·36 ± 0·12 ( S.E. of mean) vs. non-pregnant 2·33 ± 0·10 ml./min) but near term values were significantly increased (pregnant 2·80 ± 0·05 vs. non-pregnant 2·39 ± 0·05 ml./min, P < 0·001). PAH clearances were similar in pregnant and litter-mate control animals at each stage of the study. 3. Total renal weight increased significantly both early and late in pregnancy, but renal dry weights as well as [14C]choline incorporation were similar in pregnant and non-pregnant animals both at 8-10 days gestation and near term. 4. Data confirm our previous findings on renal haemodynamics in anaesthetized rats. Observations that renal dry weight and [14C]choline incorporation into phospholipids are similar in litter-mate pregnant and control animals suggests that renal enlargement in this species is due to increments in water content and not to accelerated growth." @default.
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• W2150373453 date "1980-04-01" @default.
• W2150373453 modified "2023-10-17" @default.
• W2150373453 title "Changes in renal haemodynamics and kidney weight during pregnancy in the unanaesthetized rat" @default.
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• W2150373453 doi "https://doi.org/10.1113/jphysiol.1980.sp013194" @default.
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