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- W2150374328 abstract "The LD50 of NaAsO2 was found to be 0.129 mmol/kg, sc, using white mice. The ip administration of the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) or meso-dimercaptosuccinic acid (DMSA) (0.80 mmol/kg) immediately after and 90 min after NaAsO2 increased the LD50 of NaAsO2 about 4.2- and 4.4-fold, respectively. Neither d-penicillamine nor N-acetyl-dl-penicillamine affected the LD50 of NaAsO2 under the same conditions. The LD50 of DMPS and DMSA in mice was found to be 5.22 and 13.58 mmol/kg, ip, respectively. The effective dose 50 for treating mice 10 min after receiving and LD100 of NaAsO2 (0.15 mmol/kg) was 0.066 mmol/kg for DMPS and 0.065 mmol/kg for DMSA. The therapeutic index of DMSA against 0.15 mmol/kg NaAsO2 was found to be 209. This was 2.6 times greater than that of DMPS. The explanation for this difference is that although DMSA was as effective as DMPS, it is less toxic. The LD50 of NaAsO2 was not increased by sodium diethyldithiocarbamate, α-mercaptopropionylglycine, dl-N-acetylhomocysteinethiolactone, or monomercaptosuccinic acid. A series of polymercapto compounds, some having as many as four mercapto groups per molecule, also did not protect against the lethality of NaAsO2. There is extensive experimental and clinical information about DMPS and DMSA available in the Soviet and Chinese literature where these agents are known as Unithiol or Unitiol and succimer, respectively. It would appear that DMPS and DMSA warrant further experimental studies and eventually clinical trials for the treatment of intoxication by arsenic as well as by certain other heavy metals." @default.
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- W2150374328 title "Protection of mice against the lethal effects of sodium arsenite?A quantitative comparison of a number of chelating agents*1" @default.
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- W2150374328 doi "https://doi.org/10.1016/0041-008x(81)90360-4" @default.
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