FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150387978> ?p ?o ?g. }

• W2150387978 endingPage "1578" @default.
• W2150387978 startingPage "1572" @default.
• W2150387978 abstract "ABSTRACT It has been shown that not all but most of the avian influenza viruses replicate in the upper respiratory tract of pigs (H. Kida et al., J. Gen. Virol. 75:2183-2188, 1994). It was shown that A/chicken/Yamaguchi/7/2004 (H5N1) [Ck/Yamaguchi/04 (H5N1)] did not replicate in pigs (N. Isoda et al., Arch. Virol. 151:1267-1279, 2006). In the present study, the genetic basis for this host range restriction was determined using reassortant viruses generated between Ck/Yamaguchi/04 (H5N1) and A/swine/Hokkaido/2/1981 (H1N1) [Sw/Hokkaido/81 (H1N1)]. Two in vivo-generated single-gene reassortant virus clones of the H5N1 subtype (virus clones 1 and 2), whose PB2 gene was of Sw/Hokkaido/81 (H1N1) origin and whose remaining seven genes were of Ck/Yamaguchi/04 (H5N1) origin, were recovered from the experimentally infected pigs. The replicative potential of virus clones 1 and 2 was further confirmed by using reassortant virus (rg-Ck-Sw/PB2) generated by reverse genetics. Interestingly, the PB2 gene of Ck/Yamaguchi/04 (H5N1) did not restrict the replication of Sw/Hokkaido/81 (H1N1), as determined by using reassortant virus rg-Sw-Ck/PB2. The rg-Sw-Ck/PB2 virus replicated to moderate levels and for a shorter duration than parental Sw/Hokkaido/81 (H1N1). Sequencing of two isolates recovered from the pigs inoculated with rg-Sw-Ck/PB2 revealed either the D256G or the E627K amino acid substitution in the PB2 proteins of the isolates. The D256G and E627K mutations enhanced viral polymerase activity in the mammalian cells, correlating with replication of virus in pigs. These results indicate that the PB2 protein restricts the growth of Ck/Yamaguchi/04 (H5N1) in pigs." @default.
• W2150387978 created "2016-06-24" @default.
• W2150387978 creator A5005821045 @default.
• W2150387978 creator A5012594615 @default.
• W2150387978 creator A5043427259 @default.
• W2150387978 creator A5053140479 @default.
• W2150387978 creator A5053927121 @default.
• W2150387978 creator A5054352562 @default.
• W2150387978 creator A5077518669 @default.
• W2150387978 date "2009-02-15" @default.
• W2150387978 modified "2023-10-18" @default.
• W2150387978 title "PB2 Protein of a Highly Pathogenic Avian Influenza Virus Strain A/chicken/Yamaguchi/7/2004 (H5N1) Determines Its Replication Potential in Pigs" @default.
• W2150387978 cites W1486091801 @default.
• W2150387978 cites W1526204580 @default.
• W2150387978 cites W1533200296 @default.
• W2150387978 cites W1541595517 @default.
• W2150387978 cites W1544994312 @default.
• W2150387978 cites W1603867145 @default.
• W2150387978 cites W1823620251 @default.
• W2150387978 cites W1963675143 @default.
• W2150387978 cites W1967362690 @default.
• W2150387978 cites W1971279407 @default.
• W2150387978 cites W1971447305 @default.
• W2150387978 cites W1977991935 @default.
• W2150387978 cites W1989961345 @default.
• W2150387978 cites W1995003146 @default.
• W2150387978 cites W1997704795 @default.
• W2150387978 cites W1998800643 @default.
• W2150387978 cites W1999616687 @default.
• W2150387978 cites W2018594231 @default.
• W2150387978 cites W2020316997 @default.
• W2150387978 cites W2021079566 @default.
• W2150387978 cites W2023606707 @default.
• W2150387978 cites W2029230587 @default.
• W2150387978 cites W2046469615 @default.
• W2150387978 cites W2048002397 @default.
• W2150387978 cites W2052267565 @default.
• W2150387978 cites W2057613593 @default.
• W2150387978 cites W2057700014 @default.
• W2150387978 cites W2060377782 @default.
• W2150387978 cites W2069032028 @default.
• W2150387978 cites W2069358581 @default.
• W2150387978 cites W2069513867 @default.
• W2150387978 cites W2070317697 @default.
• W2150387978 cites W2082869095 @default.
• W2150387978 cites W2089691386 @default.
• W2150387978 cites W2091527885 @default.
• W2150387978 cites W2094595216 @default.
• W2150387978 cites W2098810965 @default.
• W2150387978 cites W2104024911 @default.
• W2150387978 cites W2110034065 @default.
• W2150387978 cites W2110480900 @default.
• W2150387978 cites W2111785766 @default.
• W2150387978 cites W2112790267 @default.
• W2150387978 cites W2121240192 @default.
• W2150387978 cites W2129164111 @default.
• W2150387978 cites W2133890488 @default.
• W2150387978 cites W2143150631 @default.
• W2150387978 cites W2145688039 @default.
• W2150387978 cites W2146011840 @default.
• W2150387978 cites W2148695635 @default.
• W2150387978 cites W2148702357 @default.
• W2150387978 cites W2149940191 @default.
• W2150387978 cites W2155583328 @default.
• W2150387978 cites W2160881014 @default.
• W2150387978 cites W2164312557 @default.
• W2150387978 cites W2165690966 @default.
• W2150387978 cites W2171369029 @default.
• W2150387978 doi "https://doi.org/10.1128/jvi.01879-08" @default.
• W2150387978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2643778" @default.
• W2150387978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19052090" @default.
• W2150387978 hasPublicationYear "2009" @default.
• W2150387978 type Work @default.
• W2150387978 sameAs 2150387978 @default.
• W2150387978 citedByCount "74" @default.
• W2150387978 countsByYear W21503879782012 @default.
• W2150387978 countsByYear W21503879782013 @default.
• W2150387978 countsByYear W21503879782014 @default.
• W2150387978 countsByYear W21503879782015 @default.
• W2150387978 countsByYear W21503879782016 @default.
• W2150387978 countsByYear W21503879782017 @default.
• W2150387978 countsByYear W21503879782018 @default.
• W2150387978 countsByYear W21503879782019 @default.
• W2150387978 countsByYear W21503879782020 @default.
• W2150387978 countsByYear W21503879782021 @default.
• W2150387978 countsByYear W21503879782022 @default.
• W2150387978 countsByYear W21503879782023 @default.
• W2150387978 crossrefType "journal-article" @default.
• W2150387978 hasAuthorship W2150387978A5005821045 @default.
• W2150387978 hasAuthorship W2150387978A5012594615 @default.
• W2150387978 hasAuthorship W2150387978A5043427259 @default.
• W2150387978 hasAuthorship W2150387978A5053140479 @default.
• W2150387978 hasAuthorship W2150387978A5053927121 @default.
• W2150387978 hasAuthorship W2150387978A5054352562 @default.
• W2150387978 hasAuthorship W2150387978A5077518669 @default.
• W2150387978 hasBestOaLocation W21503879781 @default.
• W2150387978 hasConcept C104317684 @default.
• W2150387978 hasConcept C140704245 @default.

• next