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• W2150413049 abstract "Objective: Luteal phase support (LPS) is considered essential when long protocol gonadoptrophin-releasing hormone agonist (GnRH-a) is used. Progesterone is more suitable for patients with an increased risk of ovarian hyperstimulation syndrome (OHSS) and hCG is the other option. It is still not very clear which is the most suitable kind of LPS in IVF. The aim of this study was to compare the clinical and laboratory efficacy of various LPS regimens including hCG (1500 IU, every 3 days), vaginal micronised progesterone (400 mg/day), and a combination treatment of either a single dose of 3000 IU hCG or a 1500 IU every 3 days hCG added to vaginal progesterone of 400 mg/day. Design: Prospective randomised comparative study in patients with high and normal risk developing OHSS undergoing controlled ovarian hyperstimulation (COH) in an IVF programme. Materials/Methods: A total of 375 consecutive patients were included and those that were considered high-risk of developing OHSS (E23000 pg/ml, >20 follicles on hCG day, and OHSS in previous IVF attempts) were randomly allocated to receive vaginal progesterone (group A; n = 56) or vaginal progesterone combined with a single dose of hCG 3000 IU 7 days after oocyte collection (Group B; n = 56). Patients who were not considered as high-risk for OHSS were also randomly allocated to receive vaginal progesterone (Group C; n = 81), hCG 1500 IU every 3 days (group D; n = 81), and a combination of progesterone and 1500 IU hCG every 3 days (group E; n = 86). Patients were compared regarding pregnancy rates, OHSS development, duration of luteal phase and estradiol and progesterone values 7 days after oocyte collection. Results: Clinical pregnancy rates were 26%, 25%, 31%, 30%, 30% in groups A, B, C, D, and E respectively (p 0.05). Mean estradiol and progesterone levels were significantly higher in groups B, D and E compared to groups A and E (p < 0.05). Moderate to severe OHSS developed in 6, 12, 1, 10, and 14 patients in groups A, B, C, D, and E respectively. Clinical pregnancy rates were 26%, 25%, 31%, 30%, 30% in groups A, B, C, D, and E, respectively (p 0.05). Mean estradiol and progesterone levels were significantly higher in groups B, D and E compared to groups A and E (p < 0.05). Moderate to severe OHSS developed in 6, 12, 1, 10, and 14 patients in groups A, B, C, D, and E, respectively. Conclusions: LPS using hCG, vaginal micronised progesterone or a combination treatment does not alter clinical pregnancy rates. Although mean estradiol and progesterone levels are higher when hCG is used ( a reflection of corpus luteum function), pregnancy rates do not differ. OHSS risk increases in high and normal risk groups when hCG is used alone or in combination with progesterone." @default.
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• W2150413049 date "2001-09-01" @default.
• W2150413049 modified "2023-10-05" @default.
• W2150413049 title "A prospective randomized study comparing hCG, vaginal micronized progesterone and a combination regimen for luteal phase support in an in-vitro fertilization programme." @default.
• W2150413049 doi "https://doi.org/10.1016/s0015-0282(01)02345-7" @default.
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