FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150421036> ?p ?o ?g. }

• W2150421036 endingPage "e80513" @default.
• W2150421036 startingPage "e80513" @default.
• W2150421036 abstract "The APOE ε and TOMM40 rs10524523 (‘523’) variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer’s disease (AD) related phenotypes such as age of clinical onset. Hippocampal atrophy has been significantly associated with memory impairment, a characteristic of AD. The current study aimed to test for independent effects of APOE ε and TOMM40 ‘523’ genotypes on hippocampal volumes as assessed by brain structural MRI in a relatively large sample of community-dwelling older adults. As part of a longitudinal study of cognitive ageing, participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε2/ε3/ε4 status and TOMM40 ‘523’ poly-T repeat length, and detailed structural brain MRI at a mean age of 72.7 years (standard deviation = 0.7, N range = 624 to 636). No significant effects of APOE ε or TOMM40 523 genotype were found on hippocampal volumes when analysed raw, or when adjusted for either intracranial or total brain tissue volumes. In summary, in a large community-dwelling sample of older adults, we found no effects of APOE ε or TOMM40 523 genotypes on hippocampal volumes. This is discrepant with some previous reports of significant association between APOE and left/right hippocampal volumes, and instead echoes other reports that found no association. Previous significant findings may partly reflect type 1 error. Future studies should carefully consider: 1) their specific techniques in adjusting for brain size; 2) assessing more detailed sub-divisions of the hippocampal formation; and 3) testing whether significant APOE-hippocampal associations are independent of generalised brain atrophy." @default.
• W2150421036 created "2016-06-24" @default.
• W2150421036 creator A5002233555 @default.
• W2150421036 creator A5003194031 @default.
• W2150421036 creator A5028857433 @default.
• W2150421036 creator A5034776089 @default.
• W2150421036 creator A5037656149 @default.
• W2150421036 creator A5058374848 @default.
• W2150421036 creator A5059178363 @default.
• W2150421036 creator A5061348073 @default.
• W2150421036 creator A5074357173 @default.
• W2150421036 creator A5078185083 @default.
• W2150421036 creator A5079216137 @default.
• W2150421036 creator A5082869062 @default.
• W2150421036 creator A5084175530 @default.
• W2150421036 creator A5089498022 @default.
• W2150421036 date "2013-11-15" @default.
• W2150421036 modified "2023-10-09" @default.
• W2150421036 title "Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936" @default.
• W2150421036 cites W1544871434 @default.
• W2150421036 cites W1736250546 @default.
• W2150421036 cites W1974806656 @default.
• W2150421036 cites W1977920679 @default.
• W2150421036 cites W1980652623 @default.
• W2150421036 cites W1980842500 @default.
• W2150421036 cites W1981832748 @default.
• W2150421036 cites W1987474441 @default.
• W2150421036 cites W1988129374 @default.
• W2150421036 cites W1999670317 @default.
• W2150421036 cites W2006534012 @default.
• W2150421036 cites W2008205703 @default.
• W2150421036 cites W2009339691 @default.
• W2150421036 cites W2009341341 @default.
• W2150421036 cites W2010767183 @default.
• W2150421036 cites W2011563517 @default.
• W2150421036 cites W2018692335 @default.
• W2150421036 cites W2020720625 @default.
• W2150421036 cites W2021709476 @default.
• W2150421036 cites W2025267739 @default.
• W2150421036 cites W2030667927 @default.
• W2150421036 cites W2033336411 @default.
• W2150421036 cites W2034510106 @default.
• W2150421036 cites W2035888786 @default.
• W2150421036 cites W2037169299 @default.
• W2150421036 cites W2052742260 @default.
• W2150421036 cites W2055666903 @default.
• W2150421036 cites W2064552352 @default.
• W2150421036 cites W2065056564 @default.
• W2150421036 cites W2075312072 @default.
• W2150421036 cites W2076241970 @default.
• W2150421036 cites W2077816250 @default.
• W2150421036 cites W2079834962 @default.
• W2150421036 cites W2080729902 @default.
• W2150421036 cites W2085579734 @default.
• W2150421036 cites W2090271811 @default.
• W2150421036 cites W2091041552 @default.
• W2150421036 cites W2092789470 @default.
• W2150421036 cites W2103440561 @default.
• W2150421036 cites W2105102381 @default.
• W2150421036 cites W2116668074 @default.
• W2150421036 cites W2116808034 @default.
• W2150421036 cites W2121510194 @default.
• W2150421036 cites W2131298552 @default.
• W2150421036 cites W2131388554 @default.
• W2150421036 cites W2132726975 @default.
• W2150421036 cites W2132781144 @default.
• W2150421036 cites W2132948185 @default.
• W2150421036 cites W2138878035 @default.
• W2150421036 cites W2140575485 @default.
• W2150421036 cites W2141282621 @default.
• W2150421036 cites W2141346295 @default.
• W2150421036 cites W2148213577 @default.
• W2150421036 doi "https://doi.org/10.1371/journal.pone.0080513" @default.
• W2150421036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3829876" @default.
• W2150421036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24260406" @default.
• W2150421036 hasPublicationYear "2013" @default.
• W2150421036 type Work @default.
• W2150421036 sameAs 2150421036 @default.
• W2150421036 citedByCount "31" @default.
• W2150421036 countsByYear W21504210362014 @default.
• W2150421036 countsByYear W21504210362015 @default.
• W2150421036 countsByYear W21504210362016 @default.
• W2150421036 countsByYear W21504210362017 @default.
• W2150421036 countsByYear W21504210362018 @default.
• W2150421036 countsByYear W21504210362019 @default.
• W2150421036 countsByYear W21504210362020 @default.
• W2150421036 countsByYear W21504210362021 @default.
• W2150421036 countsByYear W21504210362023 @default.
• W2150421036 crossrefType "journal-article" @default.
• W2150421036 hasAuthorship W2150421036A5002233555 @default.
• W2150421036 hasAuthorship W2150421036A5003194031 @default.
• W2150421036 hasAuthorship W2150421036A5028857433 @default.
• W2150421036 hasAuthorship W2150421036A5034776089 @default.
• W2150421036 hasAuthorship W2150421036A5037656149 @default.
• W2150421036 hasAuthorship W2150421036A5058374848 @default.
• W2150421036 hasAuthorship W2150421036A5059178363 @default.
• W2150421036 hasAuthorship W2150421036A5061348073 @default.
• W2150421036 hasAuthorship W2150421036A5074357173 @default.

• next