FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150424118> ?p ?o ?g. }

• W2150424118 endingPage "446" @default.
• W2150424118 startingPage "440" @default.
• W2150424118 abstract "Abstract: Background: Many immunologically important interactions are mediated by leukocyte recognition of carbohydrates via cell surface receptors. Uncharacterized receptors on human natural killer (NK) cells interact with ligands containing the terminal Galα(1,3)Gal xenoepitope. The aim of this work was to isolate and characterize carbohydrate binding proteins from NK cells that bind αGal or other potential xenoepitopes, such as N-acetyllactosamine (NAcLac), created by the deletion of α1,3galactosyltransferase (GT) in animals. Methods and results: Initial analysis suggested the human C-type lectin NKRP1A bound to a pool of glycoconjugates, the majority of which contained the terminal Galα(1,3)Gal epitope. This was confirmed by high level binding of cells expressing NKRP1A to mouse laminin, which contains a large number of N-linked oligosaccharides with the Galα(1,3)Gal structure. The consequence of removing the terminal αGal was then investigated. Elevated NAcLac levels were observed on thymocytes from GT−/− mice. Exposing NAcLac on laminin, by α-galactosidase treatment, resulted in a significant increase in NKRP1A binding. Conclusions: NKRPIA binds to the αGal epitope. Moreover, exposing NAcLac by removal of αGal resulted in an increase in binding. This may be relevant in the later phases of xenotransplant rejection if GT−/− pigs, like GT−/− mice, display increased NAcLac expression." @default.
• W2150424118 created "2016-06-24" @default.
• W2150424118 creator A5024871281 @default.
• W2150424118 creator A5040777973 @default.
• W2150424118 creator A5049970438 @default.
• W2150424118 creator A5057364212 @default.
• W2150424118 creator A5070473478 @default.
• W2150424118 creator A5074159017 @default.
• W2150424118 date "2006-09-01" @default.
• W2150424118 modified "2023-10-14" @default.
• W2150424118 title "Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)" @default.
• W2150424118 cites W1553930358 @default.
• W2150424118 cites W1575960267 @default.
• W2150424118 cites W1803497476 @default.
• W2150424118 cites W1904297401 @default.
• W2150424118 cites W1965278955 @default.
• W2150424118 cites W1967446284 @default.
• W2150424118 cites W1967893841 @default.
• W2150424118 cites W1973050697 @default.
• W2150424118 cites W1974967880 @default.
• W2150424118 cites W1976954156 @default.
• W2150424118 cites W1978476799 @default.
• W2150424118 cites W1997076203 @default.
• W2150424118 cites W2001612894 @default.
• W2150424118 cites W2001985853 @default.
• W2150424118 cites W2007251106 @default.
• W2150424118 cites W2007610991 @default.
• W2150424118 cites W2007632920 @default.
• W2150424118 cites W2023945970 @default.
• W2150424118 cites W2041131464 @default.
• W2150424118 cites W2043122674 @default.
• W2150424118 cites W2047819151 @default.
• W2150424118 cites W2048581545 @default.
• W2150424118 cites W2058297526 @default.
• W2150424118 cites W2059456863 @default.
• W2150424118 cites W2065943556 @default.
• W2150424118 cites W2070291383 @default.
• W2150424118 cites W2071798579 @default.
• W2150424118 cites W2082003168 @default.
• W2150424118 cites W2093411130 @default.
• W2150424118 cites W2106084836 @default.
• W2150424118 cites W2108473659 @default.
• W2150424118 cites W2112998733 @default.
• W2150424118 cites W2121936687 @default.
• W2150424118 cites W2129751263 @default.
• W2150424118 cites W2146092834 @default.
• W2150424118 cites W2151164793 @default.
• W2150424118 cites W2154106683 @default.
• W2150424118 cites W2163649189 @default.
• W2150424118 cites W2169149101 @default.
• W2150424118 cites W2171709048 @default.
• W2150424118 cites W256199651 @default.
• W2150424118 doi "https://doi.org/10.1111/j.1399-3089.2006.00332.x" @default.
• W2150424118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16925668" @default.
• W2150424118 hasPublicationYear "2006" @default.
• W2150424118 type Work @default.
• W2150424118 sameAs 2150424118 @default.
• W2150424118 citedByCount "32" @default.
• W2150424118 countsByYear W21504241182012 @default.
• W2150424118 countsByYear W21504241182013 @default.
• W2150424118 countsByYear W21504241182014 @default.
• W2150424118 countsByYear W21504241182017 @default.
• W2150424118 countsByYear W21504241182018 @default.
• W2150424118 countsByYear W21504241182021 @default.
• W2150424118 crossrefType "journal-article" @default.
• W2150424118 hasAuthorship W2150424118A5024871281 @default.
• W2150424118 hasAuthorship W2150424118A5040777973 @default.
• W2150424118 hasAuthorship W2150424118A5049970438 @default.
• W2150424118 hasAuthorship W2150424118A5057364212 @default.
• W2150424118 hasAuthorship W2150424118A5070473478 @default.
• W2150424118 hasAuthorship W2150424118A5074159017 @default.
• W2150424118 hasConcept C108625454 @default.
• W2150424118 hasConcept C13426554 @default.
• W2150424118 hasConcept C147483822 @default.
• W2150424118 hasConcept C1491633281 @default.
• W2150424118 hasConcept C153911025 @default.
• W2150424118 hasConcept C170493617 @default.
• W2150424118 hasConcept C185592680 @default.
• W2150424118 hasConcept C195616568 @default.
• W2150424118 hasConcept C203014093 @default.
• W2150424118 hasConcept C2779814568 @default.
• W2150424118 hasConcept C2780758401 @default.
• W2150424118 hasConcept C55493867 @default.
• W2150424118 hasConcept C86803240 @default.
• W2150424118 hasConcept C95444343 @default.
• W2150424118 hasConceptScore W2150424118C108625454 @default.
• W2150424118 hasConceptScore W2150424118C13426554 @default.
• W2150424118 hasConceptScore W2150424118C147483822 @default.
• W2150424118 hasConceptScore W2150424118C1491633281 @default.
• W2150424118 hasConceptScore W2150424118C153911025 @default.
• W2150424118 hasConceptScore W2150424118C170493617 @default.
• W2150424118 hasConceptScore W2150424118C185592680 @default.
• W2150424118 hasConceptScore W2150424118C195616568 @default.
• W2150424118 hasConceptScore W2150424118C203014093 @default.
• W2150424118 hasConceptScore W2150424118C2779814568 @default.
• W2150424118 hasConceptScore W2150424118C2780758401 @default.
• W2150424118 hasConceptScore W2150424118C55493867 @default.
• W2150424118 hasConceptScore W2150424118C86803240 @default.

• next