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• W2150430785 abstract "Summary While naturally occurring hosts often exhibit pronounced differences in infection and pathology, the relative importance of factors associated with host life history and immunity in explaining such patterns often remains speculative. Research in eco-immunology highlights the trade-offs between host physiology and immunity, for which natural variations in disease susceptibility offer a valuable platform to test predictions within this framework. Here, we combined use of a novel, in vivo assay for tracking parasite fate and an experimental manipulation of host immune function (via chronic corticosterone exposure) to assess the role of host immunity in regulating susceptibility of amphibian hosts to three larval trematodes: Ribeiroia ondatrae, Echinostoma trivolvis, and Alaria sp. 2. Results from the in vivo parasite tracking assay revealed marked differences in initial parasite penetration and subsequent host clearance. Relative to infections in a highly susceptible species (Pseudacris regilla), the virulent trematode R. ondatrae was ~25% less successful at penetrating larvae of three hylid frog species and was cleared &gt;45× faster, such that all parasites were rapidly cleared from hylid hosts over 72 hours following a Weibull distribution. Immune suppression of Hyla versicolor sharply reduced this resistance and increased infection of all three trematodes by 67 to 190%, with particularly strong increases for Ribeiroia. Diminished resistance correlated with a 62% decrease in circulating eosinophils. Correspondingly, ten days after corticosterone exposures ended, infections declined dramatically while eosinophil levels returned to normal. In light of ongoing declines and deformities in amphibian populations, these findings have application potential for mitigating disease-driven effects." @default.
• W2150430785 created "2016-06-24" @default.
• W2150430785 creator A5021046890 @default.
• W2150430785 creator A5036710030 @default.
• W2150430785 date "2013-01-01" @default.
• W2150430785 modified "2023-10-18" @default.
• W2150430785 title "Experimental infection dynamics: using immunosuppression and<i>in vivo</i>parasite tracking to understand host resistance in an amphibian-trematode system" @default.
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• W2150430785 doi "https://doi.org/10.1242/jeb.088104" @default.
• W2150430785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23821713" @default.
• W2150430785 hasPublicationYear "2013" @default.
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