FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150437482> ?p ?o ?g. }

• W2150437482 endingPage "13" @default.
• W2150437482 startingPage "8006" @default.
• W2150437482 abstract "The current therapeutic modalities achieve low response rates in human neuroblastoma, a frequent extracranial malignancy of the early childhood. We have assessed the effect of retinoids, used presently for the treatment of neuroblastoma, on the discrete steps of the MHC class I processing machinery and susceptibility of neuroblastoma cells to CTL-mediated killing. We demonstrate that retinoic acid derivatives induce the expression of proteolytic and regulatory subunits of the immunoproteasome, increase the half-life of MHC class I complexes, and enhance the sensitivity of neuroblastoma cells to both MHC class I-restricted peptide-specific and HLA nonrestricted lysis by CTLs. Importantly, effects of retinoids on the MHC class I pathway appear to be independent of IFN-gamma and/or TNF-alpha as intermediate messengers. To our knowledge, this is the first demonstration of inflammation-unrelated biological molecules that induce systemic modulation of antigen presentation in nonprofessional antigen presenting cells. Our findings suggest that the application of retinoids and T cell-based immunotherapy may be an effective combination for the treatment of neuroblastoma." @default.
• W2150437482 created "2016-06-24" @default.
• W2150437482 creator A5028287372 @default.
• W2150437482 creator A5032012115 @default.
• W2150437482 creator A5058163888 @default.
• W2150437482 creator A5070723480 @default.
• W2150437482 creator A5078378771 @default.
• W2150437482 creator A5080084632 @default.
• W2150437482 date "2003-11-15" @default.
• W2150437482 modified "2023-10-03" @default.
• W2150437482 title "Retinoids act as multistep modulators of the major histocompatibility class I presentation pathway and sensitize neuroblastomas to cytotoxic lymphocytes." @default.
• W2150437482 cites W1503485688 @default.
• W2150437482 cites W1503805720 @default.
• W2150437482 cites W1963962536 @default.
• W2150437482 cites W1974490245 @default.
• W2150437482 cites W1978161821 @default.
• W2150437482 cites W1980039341 @default.
• W2150437482 cites W1980863092 @default.
• W2150437482 cites W1982186676 @default.
• W2150437482 cites W1984696190 @default.
• W2150437482 cites W1999574260 @default.
• W2150437482 cites W2003599638 @default.
• W2150437482 cites W2010457947 @default.
• W2150437482 cites W2013064448 @default.
• W2150437482 cites W2032774657 @default.
• W2150437482 cites W2033403710 @default.
• W2150437482 cites W2041420264 @default.
• W2150437482 cites W2042720035 @default.
• W2150437482 cites W2045470441 @default.
• W2150437482 cites W2046828698 @default.
• W2150437482 cites W2051140392 @default.
• W2150437482 cites W2058252263 @default.
• W2150437482 cites W2064598893 @default.
• W2150437482 cites W2066013797 @default.
• W2150437482 cites W2068005505 @default.
• W2150437482 cites W2072291936 @default.
• W2150437482 cites W2072451012 @default.
• W2150437482 cites W2072857456 @default.
• W2150437482 cites W2074758055 @default.
• W2150437482 cites W2078610083 @default.
• W2150437482 cites W2085962294 @default.
• W2150437482 cites W2088088839 @default.
• W2150437482 cites W2110392390 @default.
• W2150437482 cites W2113563899 @default.
• W2150437482 cites W2122515314 @default.
• W2150437482 cites W2140397231 @default.
• W2150437482 cites W2143746835 @default.
• W2150437482 cites W2145730919 @default.
• W2150437482 cites W2163595408 @default.
• W2150437482 cites W2322919527 @default.
• W2150437482 cites W2433876465 @default.
• W2150437482 cites W2461236023 @default.
• W2150437482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14633733" @default.
• W2150437482 hasPublicationYear "2003" @default.
• W2150437482 type Work @default.
• W2150437482 sameAs 2150437482 @default.
• W2150437482 citedByCount "14" @default.
• W2150437482 countsByYear W21504374822013 @default.
• W2150437482 countsByYear W21504374822015 @default.
• W2150437482 countsByYear W21504374822017 @default.
• W2150437482 countsByYear W21504374822019 @default.
• W2150437482 countsByYear W21504374822020 @default.
• W2150437482 crossrefType "journal-article" @default.
• W2150437482 hasAuthorship W2150437482A5028287372 @default.
• W2150437482 hasAuthorship W2150437482A5032012115 @default.
• W2150437482 hasAuthorship W2150437482A5058163888 @default.
• W2150437482 hasAuthorship W2150437482A5070723480 @default.
• W2150437482 hasAuthorship W2150437482A5078378771 @default.
• W2150437482 hasAuthorship W2150437482A5080084632 @default.
• W2150437482 hasConcept C108249834 @default.
• W2150437482 hasConcept C147483822 @default.
• W2150437482 hasConcept C147969180 @default.
• W2150437482 hasConcept C154317977 @default.
• W2150437482 hasConcept C167672396 @default.
• W2150437482 hasConcept C170627219 @default.
• W2150437482 hasConcept C202751555 @default.
• W2150437482 hasConcept C203014093 @default.
• W2150437482 hasConcept C207936829 @default.
• W2150437482 hasConcept C2776090121 @default.
• W2150437482 hasConcept C2776715637 @default.
• W2150437482 hasConcept C2777701055 @default.
• W2150437482 hasConcept C502942594 @default.
• W2150437482 hasConcept C54355233 @default.
• W2150437482 hasConcept C55493867 @default.
• W2150437482 hasConcept C81885089 @default.
• W2150437482 hasConcept C83464605 @default.
• W2150437482 hasConcept C86803240 @default.
• W2150437482 hasConcept C8891405 @default.
• W2150437482 hasConceptScore W2150437482C108249834 @default.
• W2150437482 hasConceptScore W2150437482C147483822 @default.
• W2150437482 hasConceptScore W2150437482C147969180 @default.
• W2150437482 hasConceptScore W2150437482C154317977 @default.
• W2150437482 hasConceptScore W2150437482C167672396 @default.
• W2150437482 hasConceptScore W2150437482C170627219 @default.
• W2150437482 hasConceptScore W2150437482C202751555 @default.
• W2150437482 hasConceptScore W2150437482C203014093 @default.
• W2150437482 hasConceptScore W2150437482C207936829 @default.
• W2150437482 hasConceptScore W2150437482C2776090121 @default.

• next