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- W2150442967 abstract "ABSTRACT A total of 46 ciprofloxacin-resistant (Cip r ) Streptococcus pneumoniae strains were isolated from 1991 to 2001 at the Hospital of Bellvitge. Five of these strains showed unexpectedly high rates of nucleotide variations in the quinolone resistance-determining regions (QRDRs) of their parC , parE , and gyrA genes. The nucleotide sequence of the full-length parC , parE , and gyrA genes of one of these isolates revealed a mosaic structure compatible with an interspecific recombination origin. Southern blot analysis and nucleotide sequence determinations showed the presence of an ant -like gene in the intergenic parE - parC regions of the S. pneumoniae Cip r isolates with high rates of variations in their parE and parC QRDRs. The ant -like gene was absent from typical S. pneumoniae strains, whereas it was present in the intergenic parE - parC regions of the viridans group streptococci ( Streptococcus mitis and Streptococcus oralis ). These results suggest that the viridans group streptococci are acting as donors in the horizontal transfer of fluoroquinolone resistance genes to S. pneumoniae ." @default.
- W2150442967 created "2016-06-24" @default.
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- W2150442967 date "2003-07-01" @default.
- W2150442967 modified "2023-10-14" @default.
- W2150442967 title "Viridans Group Streptococci Are Donors in Horizontal Transfer of Topoisomerase IV Genes to <i>Streptococcus pneumoniae</i>" @default.
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- W2150442967 doi "https://doi.org/10.1128/aac.47.7.2072-2081.2003" @default.
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