Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150450653> ?p ?o ?g. }
- W2150450653 endingPage "84" @default.
- W2150450653 startingPage "73" @default.
- W2150450653 abstract "Glial cell line-derived neurotrophic factor (GDNF), a potent neurotrophic factor, has been shown to affect cancer cell metastasis and invasion. However, the molecular mechanisms underlying GDNF-induced colon cancer cell migration remain unclear. GDNF is found to be positively correlated with malignancy in human colon cancer patients. The migratory activities of two human colon cancer cell lines, HCT116 and SW480, were found to be enhanced in the presence of human GDNF. The expression of vascular endothelial growth factor (VEGF) was also increased in response to GDNF stimulation, along with VEGF mRNA expression and transcriptional activity. The enhancement of GDNF-induced cancer cell migration was antagonized by a VEGF-neutralizing antibody. Our results also showed that the expression of VEGF receptor 1 (VEGFR1) was increased in response to GDNF stimulation, whereas GDNF-induced cancer cell migration was reduced by a VEGFR inhibitor. The GDNF-induced VEGF expression was regulated by the p38 and PI3K/Akt signaling pathways. Treatment with GDNF increased nuclear hypoxia-inducible factor 1 α (HIF1α) accumulation and its transcriptional activity in a time-dependent manner. Moreover, GDNF increased hypoxia responsive element (HRE)-containing VEGF promoter transcriptional activity but not that of the HRE-deletion VEGF promoter construct. Inhibition of HIF1α by a pharmacological inhibitor or dominant-negative mutant reduced the GDNF-induced migratory activity in human colon cancer cells. These results indicate that GDNF enhances the migration of colon cancer cells by increasing VEGF–VEGFR interaction, which is mainly regulated by the p38, PI3K/Akt, and HIF1α signaling pathways." @default.
- W2150450653 created "2016-06-24" @default.
- W2150450653 creator A5001992245 @default.
- W2150450653 creator A5025996479 @default.
- W2150450653 creator A5044117510 @default.
- W2150450653 creator A5045258122 @default.
- W2150450653 creator A5064225625 @default.
- W2150450653 creator A5066608158 @default.
- W2150450653 creator A5071947401 @default.
- W2150450653 creator A5073558272 @default.
- W2150450653 creator A5074441061 @default.
- W2150450653 creator A5085718879 @default.
- W2150450653 date "2013-10-28" @default.
- W2150450653 modified "2023-10-11" @default.
- W2150450653 title "GDNF increases cell motility in human colon cancer through VEGF–VEGFR1 interaction" @default.
- W2150450653 cites W1493048246 @default.
- W2150450653 cites W1539571840 @default.
- W2150450653 cites W1585172067 @default.
- W2150450653 cites W1967007810 @default.
- W2150450653 cites W1967543768 @default.
- W2150450653 cites W1970179076 @default.
- W2150450653 cites W1977494214 @default.
- W2150450653 cites W1980689484 @default.
- W2150450653 cites W1981173539 @default.
- W2150450653 cites W1982227923 @default.
- W2150450653 cites W1983232559 @default.
- W2150450653 cites W1984329217 @default.
- W2150450653 cites W1986308750 @default.
- W2150450653 cites W1991740099 @default.
- W2150450653 cites W1992158081 @default.
- W2150450653 cites W1993011693 @default.
- W2150450653 cites W1999436525 @default.
- W2150450653 cites W2002110095 @default.
- W2150450653 cites W2008286016 @default.
- W2150450653 cites W2010778559 @default.
- W2150450653 cites W2011813261 @default.
- W2150450653 cites W2013308056 @default.
- W2150450653 cites W2014078232 @default.
- W2150450653 cites W2014917043 @default.
- W2150450653 cites W2019726789 @default.
- W2150450653 cites W2025011904 @default.
- W2150450653 cites W2028093783 @default.
- W2150450653 cites W2030025004 @default.
- W2150450653 cites W2035005104 @default.
- W2150450653 cites W2036834043 @default.
- W2150450653 cites W2037692247 @default.
- W2150450653 cites W2042856264 @default.
- W2150450653 cites W2054050668 @default.
- W2150450653 cites W2059210843 @default.
- W2150450653 cites W2061696878 @default.
- W2150450653 cites W2062435789 @default.
- W2150450653 cites W2066000681 @default.
- W2150450653 cites W2066344481 @default.
- W2150450653 cites W2068055888 @default.
- W2150450653 cites W2069368631 @default.
- W2150450653 cites W2070407539 @default.
- W2150450653 cites W2072226549 @default.
- W2150450653 cites W2077129920 @default.
- W2150450653 cites W2082483504 @default.
- W2150450653 cites W2088116141 @default.
- W2150450653 cites W2088993031 @default.
- W2150450653 cites W2093203637 @default.
- W2150450653 cites W2094367307 @default.
- W2150450653 cites W2100739532 @default.
- W2150450653 cites W2101958952 @default.
- W2150450653 cites W2105915644 @default.
- W2150450653 cites W2111890573 @default.
- W2150450653 cites W2117923185 @default.
- W2150450653 cites W2118385155 @default.
- W2150450653 cites W2122294504 @default.
- W2150450653 cites W2123053781 @default.
- W2150450653 cites W2125724189 @default.
- W2150450653 cites W2144707486 @default.
- W2150450653 cites W2145096738 @default.
- W2150450653 cites W2146530991 @default.
- W2150450653 cites W2151596048 @default.
- W2150450653 cites W2154902011 @default.
- W2150450653 cites W2158395619 @default.
- W2150450653 cites W2163069245 @default.
- W2150450653 cites W2164621617 @default.
- W2150450653 cites W2166573361 @default.
- W2150450653 cites W2168315009 @default.
- W2150450653 cites W2169076905 @default.
- W2150450653 cites W2206542436 @default.
- W2150450653 cites W2314047078 @default.
- W2150450653 cites W2314648518 @default.
- W2150450653 cites W2326871654 @default.
- W2150450653 doi "https://doi.org/10.1530/erc-13-0351" @default.
- W2150450653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24165321" @default.
- W2150450653 hasPublicationYear "2013" @default.
- W2150450653 type Work @default.
- W2150450653 sameAs 2150450653 @default.
- W2150450653 citedByCount "36" @default.
- W2150450653 countsByYear W21504506532014 @default.
- W2150450653 countsByYear W21504506532015 @default.
- W2150450653 countsByYear W21504506532016 @default.
- W2150450653 countsByYear W21504506532017 @default.
- W2150450653 countsByYear W21504506532018 @default.