FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150460308> ?p ?o ?g. }

• W2150460308 endingPage "4934" @default.
• W2150460308 startingPage "4934" @default.
• W2150460308 abstract "To investigate the correlation of hyperlipemia (HL) and acute cerebral ischemia/reperfusion (I/R) injury on liver damage and its mechanism.Rats were divided into 4 groups: control, HL, I/R and HL+I/R. After the induction of HL via a high-fat diet for 18 wk, middle cerebral artery occlusion was followed by 24 h of reperfusion to capture I/R. Serum alanine transaminase (ALT) and aspartate aminotransferase (AST) were analyzed as part of liver function tests and liver damage was further assessed by histological examination. Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay. The expression of genes related to apoptosis (caspase-3, bcl-2) was assayed by immunohistochemistry and Western blotting. Serum tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1) and liver mitochondrial superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and Ca(2+) levels were measured to determine inflammatory and oxidative/antioxidative status respectively. Microsomal hydroxylase activity of the cytochrome P450 2E1 (CYP2E1)-containing enzyme was measured with aniline as the substrate, and CYP2E1 expression in the liver tissue and microsome was determined by immunohistochemistry and Western blotting respectively.HL alone induced by high-fat diet for 18 wk resulted in liver damage, indicated by histopathological analysis, and a considerable increase in serum ALT (25.13 ± 16.90 vs 9.56 ± 1.99, P < 0.01) and AST levels (18.01 ± 10.00 vs 11.33 ± 4.17, P < 0.05) compared with control. Moreover, HL alone induced hepatocyte apoptosis, which was determined by increased TUNEL-positive cells (4.47 ± 0.45 vs 1.5 ± 0.22, P < 0.01), higher caspase-3 and lower bcl-2 expression. Interestingly, compared with those in control, HL or I/R groups, massive increases of serum ALT (93.62 ± 24.00 vs 9.56 ± 1.99, 25.13 ± 16.90 or 12.93 ± 6.14, P < 0.01) and AST (82.32 ± 26.92 vs 11.33 ± 4.17, 18.01 ± 10.00 or 14.00 ± 6.19, P < 0.01) levels in HL+I/R group were observed suggesting severe liver damage, which was confirmed by liver histology. In addition, HL combined with I/R also caused significantly increased hepatocyte apoptosis, as evidenced by increased TUNEL-positive cells (6.20 ± 0.29 vs 1.5 ± 0.22, 4.47 ± 0.45 or 1.97 ± 0.47, P < 0.01), elevated expression of caspase-3 and lower expression of bcl-2. Furthermore, when compared to HL or I/R alone, HL plus I/R enhanced serum TNF-α, IL-1, liver mitochondrial MDA and Ca(2+) levels, suppressed SOD and GSH-Px in liver mitochondria, and markedly up-regulated the activity (11.76 ± 2.36 vs 4.77 ± 2.31 or 3.11 ± 1.35, P < 0.01) and expression (3.24 ± 0.38 vs 1.98 ± 0.88 or 1.72 ± 0.58, P < 0.01) of CYP2E1 in liver.The coexistence of HL and acute cerebral I/R induces severe liver damage, suggesting that cerebral ischemic stroke would exaggerate the damage of liver caused by HL. This effect is possibly due to enhanced CYP2E1 induction which further promotes oxidative damage, inflammation and hepatocyte apoptosis." @default.
• W2150460308 created "2016-06-24" @default.
• W2150460308 creator A5006715667 @default.
• W2150460308 creator A5008975253 @default.
• W2150460308 creator A5038490260 @default.
• W2150460308 creator A5055307680 @default.
• W2150460308 creator A5062724962 @default.
• W2150460308 creator A5062754890 @default.
• W2150460308 creator A5076828922 @default.
• W2150460308 date "2012-01-01" @default.
• W2150460308 modified "2023-09-27" @default.
• W2150460308 title "Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model" @default.
• W2150460308 cites W1534724641 @default.
• W2150460308 cites W1539472548 @default.
• W2150460308 cites W156591531 @default.
• W2150460308 cites W1775749144 @default.
• W2150460308 cites W1912658063 @default.
• W2150460308 cites W1977190397 @default.
• W2150460308 cites W1978188576 @default.
• W2150460308 cites W1988335125 @default.
• W2150460308 cites W1991177559 @default.
• W2150460308 cites W2012547073 @default.
• W2150460308 cites W2017168681 @default.
• W2150460308 cites W2025765870 @default.
• W2150460308 cites W2029114762 @default.
• W2150460308 cites W2034188379 @default.
• W2150460308 cites W2036621393 @default.
• W2150460308 cites W2039173759 @default.
• W2150460308 cites W2043875467 @default.
• W2150460308 cites W2047257800 @default.
• W2150460308 cites W2056728315 @default.
• W2150460308 cites W2062366543 @default.
• W2150460308 cites W2062883932 @default.
• W2150460308 cites W2070017052 @default.
• W2150460308 cites W2073660754 @default.
• W2150460308 cites W2080385332 @default.
• W2150460308 cites W2093491167 @default.
• W2150460308 cites W2112505121 @default.
• W2150460308 cites W2153055549 @default.
• W2150460308 cites W2156688711 @default.
• W2150460308 cites W2158718494 @default.
• W2150460308 cites W2159328192 @default.
• W2150460308 cites W2165103770 @default.
• W2150460308 cites W2408709685 @default.
• W2150460308 cites W2410825782 @default.
• W2150460308 cites W2412443444 @default.
• W2150460308 cites W3141395942 @default.
• W2150460308 cites W2102864562 @default.
• W2150460308 cites W7319844 @default.
• W2150460308 doi "https://doi.org/10.3748/wjg.v18.i35.4934" @default.
• W2150460308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3447277" @default.
• W2150460308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23002367" @default.
• W2150460308 hasPublicationYear "2012" @default.
• W2150460308 type Work @default.
• W2150460308 sameAs 2150460308 @default.
• W2150460308 citedByCount "25" @default.
• W2150460308 countsByYear W21504603082013 @default.
• W2150460308 countsByYear W21504603082014 @default.
• W2150460308 countsByYear W21504603082015 @default.
• W2150460308 countsByYear W21504603082016 @default.
• W2150460308 countsByYear W21504603082017 @default.
• W2150460308 countsByYear W21504603082018 @default.
• W2150460308 countsByYear W21504603082019 @default.
• W2150460308 countsByYear W21504603082020 @default.
• W2150460308 countsByYear W21504603082022 @default.
• W2150460308 countsByYear W21504603082023 @default.
• W2150460308 crossrefType "journal-article" @default.
• W2150460308 hasAuthorship W2150460308A5006715667 @default.
• W2150460308 hasAuthorship W2150460308A5008975253 @default.
• W2150460308 hasAuthorship W2150460308A5038490260 @default.
• W2150460308 hasAuthorship W2150460308A5055307680 @default.
• W2150460308 hasAuthorship W2150460308A5062724962 @default.
• W2150460308 hasAuthorship W2150460308A5062754890 @default.
• W2150460308 hasAuthorship W2150460308A5076828922 @default.
• W2150460308 hasBestOaLocation W21504603081 @default.
• W2150460308 hasConcept C126322002 @default.
• W2150460308 hasConcept C134018914 @default.
• W2150460308 hasConcept C140027455 @default.
• W2150460308 hasConcept C154113507 @default.
• W2150460308 hasConcept C160160445 @default.
• W2150460308 hasConcept C181199279 @default.
• W2150460308 hasConcept C196795494 @default.
• W2150460308 hasConcept C202751555 @default.
• W2150460308 hasConcept C204232928 @default.
• W2150460308 hasConcept C2775838275 @default.
• W2150460308 hasConcept C2776151105 @default.
• W2150460308 hasConcept C2776200302 @default.
• W2150460308 hasConcept C2776637226 @default.
• W2150460308 hasConcept C2778401633 @default.
• W2150460308 hasConcept C2778606649 @default.
• W2150460308 hasConcept C2778760513 @default.
• W2150460308 hasConcept C2779679107 @default.
• W2150460308 hasConcept C2780114680 @default.
• W2150460308 hasConcept C526171541 @default.
• W2150460308 hasConcept C538909803 @default.
• W2150460308 hasConcept C541997718 @default.
• W2150460308 hasConcept C55493867 @default.
• W2150460308 hasConcept C62231903 @default.

• next