FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150473092> ?p ?o ?g. }

• W2150473092 endingPage "7377" @default.
• W2150473092 startingPage "7366" @default.
• W2150473092 abstract "Local regulation of mRNA translation plays an important role in axon guidance, synaptic development, and neuronal plasticity. Little is known, however, regarding the mechanisms that control translation in neurons, and only a few mRNAs have been identified that are locally translated within axon and dendrites. Using Affymetrix gene arrays to identify mRNAs that are newly associated with polysomes after exposure to BDNF, we identified subsets of mRNAs for which translation is enhanced in neurons at different developmental stages. In mature neurons, many of these mRNAs encode proteins that are known to function at synapses, including CamKIIα, NMDA receptor subunits, and the postsynaptic density (PSD) scaffolding protein Homer2. BDNF regulates the translation of Homer2 locally in the synaptodendritic compartment by activating translational initiation via a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway. These findings suggest that BDNF likely regulates synaptic function by inducing the local synthesis of numerous synaptic proteins. The local translation of the cytoskeleton-associated protein Homer2 in particular might have important implications for growth cone dynamics and dendritic spine development." @default.
• W2150473092 created "2016-06-24" @default.
• W2150473092 creator A5002722949 @default.
• W2150473092 creator A5004088050 @default.
• W2150473092 creator A5009529380 @default.
• W2150473092 creator A5013488851 @default.
• W2150473092 creator A5068099853 @default.
• W2150473092 date "2004-08-18" @default.
• W2150473092 modified "2023-10-14" @default.
• W2150473092 title "BDNF Regulates the Translation of a Select Group of mRNAs by a Mammalian Target of Rapamycin-Phosphatidylinositol 3-Kinase-Dependent Pathway during Neuronal Development" @default.
• W2150473092 cites W1541120693 @default.
• W2150473092 cites W1584917605 @default.
• W2150473092 cites W1589135618 @default.
• W2150473092 cites W1964813963 @default.
• W2150473092 cites W1966529319 @default.
• W2150473092 cites W1973586624 @default.
• W2150473092 cites W1979496428 @default.
• W2150473092 cites W1984875632 @default.
• W2150473092 cites W1989053030 @default.
• W2150473092 cites W1995374378 @default.
• W2150473092 cites W1997486888 @default.
• W2150473092 cites W2001682430 @default.
• W2150473092 cites W2007499520 @default.
• W2150473092 cites W2010605441 @default.
• W2150473092 cites W2013122919 @default.
• W2150473092 cites W2018500072 @default.
• W2150473092 cites W2027699509 @default.
• W2150473092 cites W2036950925 @default.
• W2150473092 cites W2044273755 @default.
• W2150473092 cites W2047884170 @default.
• W2150473092 cites W2056994440 @default.
• W2150473092 cites W2060612467 @default.
• W2150473092 cites W2063089911 @default.
• W2150473092 cites W2069181654 @default.
• W2150473092 cites W2069705491 @default.
• W2150473092 cites W2074698464 @default.
• W2150473092 cites W2080252952 @default.
• W2150473092 cites W2096473946 @default.
• W2150473092 cites W2100444823 @default.
• W2150473092 cites W2105322114 @default.
• W2150473092 cites W2109851824 @default.
• W2150473092 cites W2137433892 @default.
• W2150473092 cites W2138505246 @default.
• W2150473092 cites W2150443013 @default.
• W2150473092 cites W2153068303 @default.
• W2150473092 cites W2160769038 @default.
• W2150473092 cites W2163382569 @default.
• W2150473092 cites W2166530541 @default.
• W2150473092 cites W2168096237 @default.
• W2150473092 cites W2441629306 @default.
• W2150473092 doi "https://doi.org/10.1523/jneurosci.1739-04.2004" @default.
• W2150473092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729778" @default.
• W2150473092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15317862" @default.
• W2150473092 hasPublicationYear "2004" @default.
• W2150473092 type Work @default.
• W2150473092 sameAs 2150473092 @default.
• W2150473092 citedByCount "379" @default.
• W2150473092 countsByYear W21504730922012 @default.
• W2150473092 countsByYear W21504730922013 @default.
• W2150473092 countsByYear W21504730922014 @default.
• W2150473092 countsByYear W21504730922015 @default.
• W2150473092 countsByYear W21504730922016 @default.
• W2150473092 countsByYear W21504730922017 @default.
• W2150473092 countsByYear W21504730922018 @default.
• W2150473092 countsByYear W21504730922019 @default.
• W2150473092 countsByYear W21504730922020 @default.
• W2150473092 countsByYear W21504730922021 @default.
• W2150473092 countsByYear W21504730922022 @default.
• W2150473092 countsByYear W21504730922023 @default.
• W2150473092 crossrefType "journal-article" @default.
• W2150473092 hasAuthorship W2150473092A5002722949 @default.
• W2150473092 hasAuthorship W2150473092A5004088050 @default.
• W2150473092 hasAuthorship W2150473092A5009529380 @default.
• W2150473092 hasAuthorship W2150473092A5013488851 @default.
• W2150473092 hasAuthorship W2150473092A5068099853 @default.
• W2150473092 hasBestOaLocation W21504730921 @default.
• W2150473092 hasConcept C104317684 @default.
• W2150473092 hasConcept C105580179 @default.
• W2150473092 hasConcept C135903288 @default.
• W2150473092 hasConcept C148762608 @default.
• W2150473092 hasConcept C149364088 @default.
• W2150473092 hasConcept C169760540 @default.
• W2150473092 hasConcept C170493617 @default.
• W2150473092 hasConcept C174884520 @default.
• W2150473092 hasConcept C187541742 @default.
• W2150473092 hasConcept C2779530196 @default.
• W2150473092 hasConcept C53645450 @default.
• W2150473092 hasConcept C54355233 @default.
• W2150473092 hasConcept C62478195 @default.
• W2150473092 hasConcept C69125201 @default.
• W2150473092 hasConcept C86803240 @default.
• W2150473092 hasConcept C95444343 @default.
• W2150473092 hasConcept C98229152 @default.
• W2150473092 hasConceptScore W2150473092C104317684 @default.
• W2150473092 hasConceptScore W2150473092C105580179 @default.
• W2150473092 hasConceptScore W2150473092C135903288 @default.
• W2150473092 hasConceptScore W2150473092C148762608 @default.
• W2150473092 hasConceptScore W2150473092C149364088 @default.

• next