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• W2150473299 startingPage "365" @default.
• W2150473299 abstract "Carriers of a double thrombophilic mutation (factor V Leiden and prothrombin G20210A) are at high risk of a recurrent venous thromboembolism (VTE), and may benefit from a longer course of secondary prophylaxis. We examined the costs and health benefits of screening for both the mutations, provided that double heterozygotes undergo 2 years of anticoagulation as compared to the standard 6 months. We thus pooled the available evidence and calculated that the OR for recurrence in double heterozygotes was 5.9 (95% CI 2.65–13.20). A Markov model tracked patients’ health lifelong, and calculated that prolonged prophylaxis saved 26 quality‐adjusted days of life and $410 per double heterozygote treated. Screening all the patients with venous thromboembolism thus provided one additional day of life at the cost of 13624 $/QALY (95% CI 12 965–22 889). Screening was not cost‐effective in those cohorts with a low prevalence of the mutations, a high bleeding risk or in those where prophylaxis prevented <65% of recurrences. Screening for factor V Leiden and prothrombin G20210A, with prolonged prophylaxis of double carriers, is cost‐effective in most patients with VTE." @default.
• W2150473299 created "2016-06-24" @default.
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• W2150473299 date "2001-07-01" @default.
• W2150473299 modified "2023-10-16" @default.
• W2150473299 title "Cost-effectiveness of screening and extended anticoagulation for carriers of both factor V Leiden and prothrombin G20210A" @default.
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• W2150473299 doi "https://doi.org/10.1093/qjmed/94.7.365" @default.
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