FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150484311> ?p ?o ?g. }

• W2150484311 endingPage "3245" @default.
• W2150484311 startingPage "3238" @default.
• W2150484311 abstract "A fully synthetic carbohydrate-based cancer vaccine is an attractive concept, but an important topic in the area is to develop proper vaccine carriers that can improve the immunogenicity and other immunological properties of tumor-associated carbohydrate antigens (TACAs). In this context, four monophosphoryl derivatives of Neisseria meningitidis lipid A were synthesized via a highly convergent and effective strategy and evaluated as vaccine carriers and adjuvants. The conjugates of these monophosphoryl lipid A (MPLA) derivatives with a modified form of the sTn antigen were found to elicit high titers of antigen-specific IgG antibodies, indicating a T cell-dependent immune response, in the absence of an external adjuvant. It was concluded that MPLAs could be utilized as potent vaccine carriers and built-in adjuvants to create fully synthetic self-adjuvanting carbohydrate-based cancer vaccines. The lipid composition and structure of MPLA were shown to have a significant influence on its immunological activity, and among the MPLAs examined, natural N. meningitidis MPLA exhibited the most promising properties. Moreover, Titermax Gold, a conventional vaccine adjuvant, was shown to inhibit, rather than promote, the immunological activity of MPLA conjugates, maybe via interacting with MPLA." @default.
• W2150484311 created "2016-06-24" @default.
• W2150484311 creator A5014678629 @default.
• W2150484311 creator A5031295790 @default.
• W2150484311 creator A5048423176 @default.
• W2150484311 creator A5051316812 @default.
• W2150484311 date "2014-01-01" @default.
• W2150484311 modified "2023-09-25" @default.
• W2150484311 title "Synthesis and evaluation of monophosphoryl lipid A derivatives as fully synthetic self-adjuvanting glycoconjugate cancer vaccine carriers" @default.
• W2150484311 cites W1749893864 @default.
• W2150484311 cites W1880952878 @default.
• W2150484311 cites W1886645137 @default.
• W2150484311 cites W1971353492 @default.
• W2150484311 cites W1973289030 @default.
• W2150484311 cites W1983073871 @default.
• W2150484311 cites W1987016144 @default.
• W2150484311 cites W1995573468 @default.
• W2150484311 cites W1997223193 @default.
• W2150484311 cites W2003444408 @default.
• W2150484311 cites W2012510102 @default.
• W2150484311 cites W2018453381 @default.
• W2150484311 cites W2019479596 @default.
• W2150484311 cites W2023990508 @default.
• W2150484311 cites W2036196494 @default.
• W2150484311 cites W2036559169 @default.
• W2150484311 cites W2038270516 @default.
• W2150484311 cites W2051798896 @default.
• W2150484311 cites W2054461329 @default.
• W2150484311 cites W2054766392 @default.
• W2150484311 cites W2055260115 @default.
• W2150484311 cites W2072347337 @default.
• W2150484311 cites W2072390296 @default.
• W2150484311 cites W2080291063 @default.
• W2150484311 cites W2081341992 @default.
• W2150484311 cites W2082718424 @default.
• W2150484311 cites W2086261718 @default.
• W2150484311 cites W2086447798 @default.
• W2150484311 cites W2089926816 @default.
• W2150484311 cites W2092293554 @default.
• W2150484311 cites W2092591554 @default.
• W2150484311 cites W2131392583 @default.
• W2150484311 cites W2135720956 @default.
• W2150484311 cites W2138327220 @default.
• W2150484311 cites W2146948320 @default.
• W2150484311 cites W2150024246 @default.
• W2150484311 cites W2164094601 @default.
• W2150484311 cites W2167991675 @default.
• W2150484311 cites W2171217845 @default.
• W2150484311 doi "https://doi.org/10.1039/c4ob00390j" @default.
• W2150484311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4074652" @default.
• W2150484311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24728423" @default.
• W2150484311 hasPublicationYear "2014" @default.
• W2150484311 type Work @default.
• W2150484311 sameAs 2150484311 @default.
• W2150484311 citedByCount "67" @default.
• W2150484311 countsByYear W21504843112015 @default.
• W2150484311 countsByYear W21504843112016 @default.
• W2150484311 countsByYear W21504843112017 @default.
• W2150484311 countsByYear W21504843112018 @default.
• W2150484311 countsByYear W21504843112019 @default.
• W2150484311 countsByYear W21504843112020 @default.
• W2150484311 countsByYear W21504843112021 @default.
• W2150484311 countsByYear W21504843112022 @default.
• W2150484311 countsByYear W21504843112023 @default.
• W2150484311 crossrefType "journal-article" @default.
• W2150484311 hasAuthorship W2150484311A5014678629 @default.
• W2150484311 hasAuthorship W2150484311A5031295790 @default.
• W2150484311 hasAuthorship W2150484311A5048423176 @default.
• W2150484311 hasAuthorship W2150484311A5051316812 @default.
• W2150484311 hasBestOaLocation W21504843112 @default.
• W2150484311 hasConcept C13426554 @default.
• W2150484311 hasConcept C144464004 @default.
• W2150484311 hasConcept C147483822 @default.
• W2150484311 hasConcept C151730666 @default.
• W2150484311 hasConcept C159654299 @default.
• W2150484311 hasConcept C185592680 @default.
• W2150484311 hasConcept C203014093 @default.
• W2150484311 hasConcept C2777701055 @default.
• W2150484311 hasConcept C2777863537 @default.
• W2150484311 hasConcept C2778378633 @default.
• W2150484311 hasConcept C2778458888 @default.
• W2150484311 hasConcept C2778754761 @default.
• W2150484311 hasConcept C2779343474 @default.
• W2150484311 hasConcept C2780868878 @default.
• W2150484311 hasConcept C523546767 @default.
• W2150484311 hasConcept C54355233 @default.
• W2150484311 hasConcept C55493867 @default.
• W2150484311 hasConcept C86803240 @default.
• W2150484311 hasConcept C8891405 @default.
• W2150484311 hasConceptScore W2150484311C13426554 @default.
• W2150484311 hasConceptScore W2150484311C144464004 @default.
• W2150484311 hasConceptScore W2150484311C147483822 @default.
• W2150484311 hasConceptScore W2150484311C151730666 @default.
• W2150484311 hasConceptScore W2150484311C159654299 @default.
• W2150484311 hasConceptScore W2150484311C185592680 @default.
• W2150484311 hasConceptScore W2150484311C203014093 @default.
• W2150484311 hasConceptScore W2150484311C2777701055 @default.
• W2150484311 hasConceptScore W2150484311C2777863537 @default.

• next