Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150487321> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2150487321 endingPage "941" @default.
- W2150487321 startingPage "938" @default.
- W2150487321 abstract "Ret rearrangements are common in papillary thyroid carcinoma (PTC), with ret/PTC-3 commonly seen in children exposed to ionizing radiation. In this context ret/PTC-3 has been correlated with solid variant morphology, poorer prognosis, and aggressive tumor behavior. We aimed to assess the prevalence of the common ret chimeric transcripts (ret/PTC-1 and ret/PTC-3) in a group of sporadic PTC and correlate them with tumor morphology. Thyroid follicular cells were laser capture microdissected from sections of archival PTC (n = 28). Total RNA was extracted and analyzed for expression of glyceraldehyde 3-phosphate dehydrogenase, ret/PTC-1, and ret/PTC-3 using TaqMan PCR. Ret/PTC rearrangements were detected in 60% of PTCs. Specifically transcripts of ret/PTC-1 and ret/PTC-3 were detected in 43% and 18% of PTCs, respectively. Ret/PTC-3 was detected in only follicular variant subtype (60%) and was not detected in classic PTC. One case of tall cell variant demonstrated chimeric expression of both ret/PTC-1 and ret/PTC-3 transcripts within the same tumor. This study demonstrated a high prevalence of the two common ret rearrangements in an Irish cohort of PTCs. A correlation of tumor morphology with these common ret rearrangements is suggested." @default.
- W2150487321 created "2016-06-24" @default.
- W2150487321 creator A5009176963 @default.
- W2150487321 creator A5020210703 @default.
- W2150487321 creator A5023406772 @default.
- W2150487321 creator A5026896228 @default.
- W2150487321 creator A5043621658 @default.
- W2150487321 date "2003-02-01" @default.
- W2150487321 modified "2023-10-16" @default.
- W2150487321 title "Ret/PTC Chimeric Transcripts in an Irish Cohort of Sporadic Papillary Thyroid Carcinoma" @default.
- W2150487321 cites W1506952471 @default.
- W2150487321 cites W1911853914 @default.
- W2150487321 cites W1978546090 @default.
- W2150487321 cites W1989924283 @default.
- W2150487321 cites W1990323829 @default.
- W2150487321 cites W1994486839 @default.
- W2150487321 cites W2007781242 @default.
- W2150487321 cites W2021091222 @default.
- W2150487321 cites W2023551756 @default.
- W2150487321 cites W2036011846 @default.
- W2150487321 cites W2036363386 @default.
- W2150487321 cites W2037582263 @default.
- W2150487321 cites W2042752722 @default.
- W2150487321 cites W2051782478 @default.
- W2150487321 cites W2057615313 @default.
- W2150487321 cites W2059964515 @default.
- W2150487321 cites W2071749936 @default.
- W2150487321 cites W2094949762 @default.
- W2150487321 cites W2098551699 @default.
- W2150487321 cites W2142173193 @default.
- W2150487321 cites W2143501369 @default.
- W2150487321 cites W2313490944 @default.
- W2150487321 cites W2408912347 @default.
- W2150487321 doi "https://doi.org/10.1210/jc.2002-021239" @default.
- W2150487321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12574236" @default.
- W2150487321 hasPublicationYear "2003" @default.
- W2150487321 type Work @default.
- W2150487321 sameAs 2150487321 @default.
- W2150487321 citedByCount "20" @default.
- W2150487321 countsByYear W21504873212012 @default.
- W2150487321 countsByYear W21504873212019 @default.
- W2150487321 crossrefType "journal-article" @default.
- W2150487321 hasAuthorship W2150487321A5009176963 @default.
- W2150487321 hasAuthorship W2150487321A5020210703 @default.
- W2150487321 hasAuthorship W2150487321A5023406772 @default.
- W2150487321 hasAuthorship W2150487321A5026896228 @default.
- W2150487321 hasAuthorship W2150487321A5043621658 @default.
- W2150487321 hasConcept C126322002 @default.
- W2150487321 hasConcept C142724271 @default.
- W2150487321 hasConcept C151730666 @default.
- W2150487321 hasConcept C2779343474 @default.
- W2150487321 hasConcept C2993294228 @default.
- W2150487321 hasConcept C502942594 @default.
- W2150487321 hasConcept C526584372 @default.
- W2150487321 hasConcept C71924100 @default.
- W2150487321 hasConcept C86803240 @default.
- W2150487321 hasConceptScore W2150487321C126322002 @default.
- W2150487321 hasConceptScore W2150487321C142724271 @default.
- W2150487321 hasConceptScore W2150487321C151730666 @default.
- W2150487321 hasConceptScore W2150487321C2779343474 @default.
- W2150487321 hasConceptScore W2150487321C2993294228 @default.
- W2150487321 hasConceptScore W2150487321C502942594 @default.
- W2150487321 hasConceptScore W2150487321C526584372 @default.
- W2150487321 hasConceptScore W2150487321C71924100 @default.
- W2150487321 hasConceptScore W2150487321C86803240 @default.
- W2150487321 hasIssue "2" @default.
- W2150487321 hasLocation W21504873211 @default.
- W2150487321 hasLocation W21504873212 @default.
- W2150487321 hasOpenAccess W2150487321 @default.
- W2150487321 hasPrimaryLocation W21504873211 @default.
- W2150487321 hasRelatedWork W1883339594 @default.
- W2150487321 hasRelatedWork W1970870200 @default.
- W2150487321 hasRelatedWork W1983640290 @default.
- W2150487321 hasRelatedWork W1992191048 @default.
- W2150487321 hasRelatedWork W2403914000 @default.
- W2150487321 hasRelatedWork W3014357754 @default.
- W2150487321 hasRelatedWork W3017019859 @default.
- W2150487321 hasRelatedWork W4214948555 @default.
- W2150487321 hasRelatedWork W4247376880 @default.
- W2150487321 hasRelatedWork W2114773524 @default.
- W2150487321 hasVolume "88" @default.
- W2150487321 isParatext "false" @default.
- W2150487321 isRetracted "false" @default.
- W2150487321 magId "2150487321" @default.
- W2150487321 workType "article" @default.