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• W2150489151 abstract "In patients with chronic lymphocytic leukemia (CLL), effector and memory CD4 + and CD8 + T cells are expanded. We investigated whether these CLL specific T-cell expansions also occur in monoclonal B lymphocytosis (MBL), the pre-leukemic state of CLL, which is currently distinguished from CLL by an arbitrarily chosen cut-off value of CD19 of 5.0 × 109/L. Whereas an increase in effector and memory CD4 + and CD8 + T cells was found in CLL, these expansions could not be found in MBL. Although a significant correlation was found between absolute B cell count (CD19) and T cell numbers, correlation coefficients were rather low. Therefore, we analyzed whether an optimal threshold for CD19 number could be defined which best related to an expansion of T cells. The B-cell threshold that best predicted expansion of CD3 +, CD4 + and CD8 + T cells, respectively, was 10 × 109/L. Our study indicates that a higher cut-off value than the current 5.0 × 109/L relates better to the biological impact of CLL." @default.
• W2150489151 created "2016-06-24" @default.
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• W2150489151 date "2012-08-25" @default.
• W2150489151 modified "2023-09-28" @default.
• W2150489151 title "Chronic lymphocytic leukemia specific T-cell subset alterations are clone-size dependent and not present in monoclonal B lymphocytosis" @default.
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• W2150489151 doi "https://doi.org/10.3109/10428194.2012.698277" @default.
• W2150489151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22646856" @default.
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