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- W2150492086 endingPage "11360" @default.
- W2150492086 startingPage "11356" @default.
- W2150492086 abstract "The development of a new photolabile protecting group containing an additional allyl functionality allows the synthesis of cyclic photoactivatable natural products. Cyclization occurs between the allyl moiety in the protecting group and a second double bond in the target molecule by means of ring-closing metathesis. Cyclization should increase the metabolic stability towards proteases. On the other hand, the conformational change should cause diminished biological activity. As illustrated for tubulysin derivatives, cyclic and photoactivatable drug candidates can easily be obtained in only two steps from simple building blocks through Ugi reaction and ring-closing metathesis. The photolabile protecting group is introduced by means of the isocyanide component during the Ugi reaction." @default.
- W2150492086 created "2016-06-24" @default.
- W2150492086 creator A5061469760 @default.
- W2150492086 creator A5088253534 @default.
- W2150492086 date "2014-09-04" @default.
- W2150492086 modified "2023-10-01" @default.
- W2150492086 title "A Straightforward Approach towards Cyclic Photoactivatable Tubulysin Derivatives" @default.
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- W2150492086 doi "https://doi.org/10.1002/anie.201405650" @default.
- W2150492086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25196233" @default.
- W2150492086 hasPublicationYear "2014" @default.