FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150492098> ?p ?o ?g. }

• W2150492098 endingPage "1066" @default.
• W2150492098 startingPage "1059" @default.
• W2150492098 abstract "The effects of ethanol on brain function are thought to be partly because of altered activity of ion channels that regulate synaptic activity. Results from previous studies from this lab and others have shown that ethanol inhibits the function of the N-methyl-D-aspartate (NMDA) receptors, a calcium-permeable ion channel activated by the neurotransmitter glutamate. Factors that influence the acute sensitivity of NMDA receptors to ethanol may be critical in determining how neurons and neuronal networks respond to the presence of ethanol. In this study, we have examined the effect of physiologically relevant concentrations of magnesium on the ethanol sensitivity of recombinant NMDA receptors and how ethanol inhibition under these conditions is influenced by the NR3A subunit.Recombinant cDNAs encoding NMDA receptor subunits were expressed in human embryonic kidney 293 cells. Whole-cell patch-clamp electrophysiology was used to measure currents induced by rapid application of glutamate in the absence and presence of ethanol.In magnesium-free recording solution, ethanol inhibited glutamate-mediated currents in cells transfected with NMDA receptor subunits. The magnitude of ethanol inhibition was significantly enhanced when recordings were carried out in media containing 1 mM magnesium. This effect was reversible and required magnesium-sensitive receptors. Magnesium did not enhance ethanol inhibition of glycine-activated NR1/NR3A/NR3B receptors. However, NR3A co-expression prevented the enhancement of ethanol's inhibitory effect on receptors composed of NR2A but not NR2B subunits.These results suggest that under physiological conditions, NR3A may be an important regulator of the acute ethanol sensitivity of brain NMDA receptors." @default.
• W2150492098 created "2016-06-24" @default.
• W2150492098 creator A5081525770 @default.
• W2150492098 creator A5086757835 @default.
• W2150492098 creator A5089537504 @default.
• W2150492098 date "2008-06-01" @default.
• W2150492098 modified "2023-10-16" @default.
• W2150492098 title "Enhanced Ethanol Inhibition of Recombinant N-methyl-D-aspartate Receptors by Magnesium: Role of NR3A Subunits" @default.
• W2150492098 cites W1863375292 @default.
• W2150492098 cites W1919210158 @default.
• W2150492098 cites W1969811315 @default.
• W2150492098 cites W1977048478 @default.
• W2150492098 cites W1983807711 @default.
• W2150492098 cites W1998551383 @default.
• W2150492098 cites W2002637649 @default.
• W2150492098 cites W2003636640 @default.
• W2150492098 cites W2003849824 @default.
• W2150492098 cites W2006952262 @default.
• W2150492098 cites W2007816267 @default.
• W2150492098 cites W2011275122 @default.
• W2150492098 cites W2013812562 @default.
• W2150492098 cites W2015830285 @default.
• W2150492098 cites W2017253439 @default.
• W2150492098 cites W2034351812 @default.
• W2150492098 cites W2053980736 @default.
• W2150492098 cites W2054647522 @default.
• W2150492098 cites W2058744646 @default.
• W2150492098 cites W2062928716 @default.
• W2150492098 cites W2063248367 @default.
• W2150492098 cites W2065169750 @default.
• W2150492098 cites W2067669919 @default.
• W2150492098 cites W2073537077 @default.
• W2150492098 cites W2076283597 @default.
• W2150492098 cites W2092156269 @default.
• W2150492098 cites W2095472109 @default.
• W2150492098 cites W2100824868 @default.
• W2150492098 cites W2122010285 @default.
• W2150492098 cites W2148602445 @default.
• W2150492098 cites W2150106592 @default.
• W2150492098 cites W2164014355 @default.
• W2150492098 cites W99057588 @default.
• W2150492098 doi "https://doi.org/10.1111/j.1530-0277.2008.00667.x" @default.
• W2150492098 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3590455" @default.
• W2150492098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18445116" @default.
• W2150492098 hasPublicationYear "2008" @default.
• W2150492098 type Work @default.
• W2150492098 sameAs 2150492098 @default.
• W2150492098 citedByCount "25" @default.
• W2150492098 countsByYear W21504920982012 @default.
• W2150492098 countsByYear W21504920982013 @default.
• W2150492098 countsByYear W21504920982014 @default.
• W2150492098 countsByYear W21504920982015 @default.
• W2150492098 countsByYear W21504920982016 @default.
• W2150492098 countsByYear W21504920982017 @default.
• W2150492098 countsByYear W21504920982018 @default.
• W2150492098 countsByYear W21504920982022 @default.
• W2150492098 countsByYear W21504920982023 @default.
• W2150492098 crossrefType "journal-article" @default.
• W2150492098 hasAuthorship W2150492098A5081525770 @default.
• W2150492098 hasAuthorship W2150492098A5086757835 @default.
• W2150492098 hasAuthorship W2150492098A5089537504 @default.
• W2150492098 hasBestOaLocation W21504920982 @default.
• W2150492098 hasConcept C12554922 @default.
• W2150492098 hasConcept C147944092 @default.
• W2150492098 hasConcept C169760540 @default.
• W2150492098 hasConcept C170493617 @default.
• W2150492098 hasConcept C17077164 @default.
• W2150492098 hasConcept C185592680 @default.
• W2150492098 hasConcept C2777756961 @default.
• W2150492098 hasConcept C2780161600 @default.
• W2150492098 hasConcept C35599011 @default.
• W2150492098 hasConcept C515207424 @default.
• W2150492098 hasConcept C55493867 @default.
• W2150492098 hasConcept C61174792 @default.
• W2150492098 hasConcept C67018056 @default.
• W2150492098 hasConcept C86803240 @default.
• W2150492098 hasConcept C95444343 @default.
• W2150492098 hasConcept C98274493 @default.
• W2150492098 hasConceptScore W2150492098C12554922 @default.
• W2150492098 hasConceptScore W2150492098C147944092 @default.
• W2150492098 hasConceptScore W2150492098C169760540 @default.
• W2150492098 hasConceptScore W2150492098C170493617 @default.
• W2150492098 hasConceptScore W2150492098C17077164 @default.
• W2150492098 hasConceptScore W2150492098C185592680 @default.
• W2150492098 hasConceptScore W2150492098C2777756961 @default.
• W2150492098 hasConceptScore W2150492098C2780161600 @default.
• W2150492098 hasConceptScore W2150492098C35599011 @default.
• W2150492098 hasConceptScore W2150492098C515207424 @default.
• W2150492098 hasConceptScore W2150492098C55493867 @default.
• W2150492098 hasConceptScore W2150492098C61174792 @default.
• W2150492098 hasConceptScore W2150492098C67018056 @default.
• W2150492098 hasConceptScore W2150492098C86803240 @default.
• W2150492098 hasConceptScore W2150492098C95444343 @default.
• W2150492098 hasConceptScore W2150492098C98274493 @default.
• W2150492098 hasIssue "6" @default.
• W2150492098 hasLocation W21504920981 @default.
• W2150492098 hasLocation W21504920982 @default.
• W2150492098 hasLocation W21504920983 @default.

• next