Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150504900> ?p ?o ?g. }
- W2150504900 endingPage "182" @default.
- W2150504900 startingPage "171" @default.
- W2150504900 abstract "The hepatitis B virus-encoded X antigen (HBxAg) may contribute to the development of liver cancer, in part, by stimulating the growth and survival of infected cells in the face of ongoing immune responses. Given that the Fas ligand/receptor system contributes to the pathogenesis of chronic hepatitis B, experiments were designed to test the hypothesis that HBxAg mediates resistance of liver cells to anti-Fas killing. Accordingly, when HBxAg was introduced into HepG2 cells, it rendered these cells partially resistant to killing by anti-Fas. In HepG2 cells replicating virus, protection against anti-Fas killing was also observed, but to a lesser extent. Survival correlated with the activation of nuclear factor kappa B (NF-kappa B) by HBxAg. Sensitivity to anti-Fas was observed in control cells, and was re-established in HepG2X cells stably transfected with the dominant negative inhibitor of NF-kappa B, I kappa B alpha. HBxAg activation of NF-kappa B was also associated with decreased levels of endogenous I kappa B alpha mRNA. Hence, HBxAg stimulation of NF-kappa B promotes the survival of liver cells against Fas killing. This may contribute to the persistence of infected hepatocytes during chronic infection." @default.
- W2150504900 created "2016-06-24" @default.
- W2150504900 creator A5045947801 @default.
- W2150504900 creator A5047696180 @default.
- W2150504900 creator A5050619824 @default.
- W2150504900 creator A5056078513 @default.
- W2150504900 date "2001-01-01" @default.
- W2150504900 modified "2023-10-12" @default.
- W2150504900 title "Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-κB" @default.
- W2150504900 cites W1480852720 @default.
- W2150504900 cites W1492606093 @default.
- W2150504900 cites W1511984367 @default.
- W2150504900 cites W158638529 @default.
- W2150504900 cites W1591152328 @default.
- W2150504900 cites W1656404511 @default.
- W2150504900 cites W1667463872 @default.
- W2150504900 cites W1671694443 @default.
- W2150504900 cites W1796170190 @default.
- W2150504900 cites W1799117517 @default.
- W2150504900 cites W1888783223 @default.
- W2150504900 cites W1962682498 @default.
- W2150504900 cites W1971715709 @default.
- W2150504900 cites W1973390904 @default.
- W2150504900 cites W1979333059 @default.
- W2150504900 cites W1982062664 @default.
- W2150504900 cites W1986150533 @default.
- W2150504900 cites W1987764628 @default.
- W2150504900 cites W1989600187 @default.
- W2150504900 cites W1991355519 @default.
- W2150504900 cites W1996884717 @default.
- W2150504900 cites W2008608024 @default.
- W2150504900 cites W2010338556 @default.
- W2150504900 cites W2011607753 @default.
- W2150504900 cites W2013054809 @default.
- W2150504900 cites W2026156952 @default.
- W2150504900 cites W2031035856 @default.
- W2150504900 cites W2032555321 @default.
- W2150504900 cites W2032781689 @default.
- W2150504900 cites W2034296773 @default.
- W2150504900 cites W2035280748 @default.
- W2150504900 cites W2045463981 @default.
- W2150504900 cites W2045796964 @default.
- W2150504900 cites W2046817046 @default.
- W2150504900 cites W2050274505 @default.
- W2150504900 cites W2053372168 @default.
- W2150504900 cites W2056570769 @default.
- W2150504900 cites W2058349670 @default.
- W2150504900 cites W2065257477 @default.
- W2150504900 cites W2066868766 @default.
- W2150504900 cites W2067279573 @default.
- W2150504900 cites W2067534266 @default.
- W2150504900 cites W2069008988 @default.
- W2150504900 cites W2070490299 @default.
- W2150504900 cites W2073993982 @default.
- W2150504900 cites W2075809552 @default.
- W2150504900 cites W2076231007 @default.
- W2150504900 cites W2082575834 @default.
- W2150504900 cites W2095777941 @default.
- W2150504900 cites W2097587406 @default.
- W2150504900 cites W2105394306 @default.
- W2150504900 cites W2127163321 @default.
- W2150504900 cites W2130910183 @default.
- W2150504900 cites W2144206181 @default.
- W2150504900 cites W2150488718 @default.
- W2150504900 cites W2161261662 @default.
- W2150504900 cites W2162421166 @default.
- W2150504900 cites W2314214777 @default.
- W2150504900 cites W2320182093 @default.
- W2150504900 cites W2334955709 @default.
- W2150504900 cites W4229992754 @default.
- W2150504900 cites W4254682396 @default.
- W2150504900 doi "https://doi.org/10.1099/0022-1317-82-1-171" @default.
- W2150504900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11125170" @default.
- W2150504900 hasPublicationYear "2001" @default.
- W2150504900 type Work @default.
- W2150504900 sameAs 2150504900 @default.
- W2150504900 citedByCount "101" @default.
- W2150504900 countsByYear W21505049002012 @default.
- W2150504900 countsByYear W21505049002013 @default.
- W2150504900 countsByYear W21505049002014 @default.
- W2150504900 countsByYear W21505049002015 @default.
- W2150504900 countsByYear W21505049002016 @default.
- W2150504900 countsByYear W21505049002017 @default.
- W2150504900 countsByYear W21505049002018 @default.
- W2150504900 countsByYear W21505049002019 @default.
- W2150504900 countsByYear W21505049002020 @default.
- W2150504900 countsByYear W21505049002021 @default.
- W2150504900 countsByYear W21505049002022 @default.
- W2150504900 crossrefType "journal-article" @default.
- W2150504900 hasAuthorship W2150504900A5045947801 @default.
- W2150504900 hasAuthorship W2150504900A5047696180 @default.
- W2150504900 hasAuthorship W2150504900A5050619824 @default.
- W2150504900 hasAuthorship W2150504900A5056078513 @default.
- W2150504900 hasBestOaLocation W21505049001 @default.
- W2150504900 hasConcept C153911025 @default.
- W2150504900 hasConcept C159047783 @default.
- W2150504900 hasConcept C190283241 @default.
- W2150504900 hasConcept C203014093 @default.