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- W2150536616 endingPage "1386" @default.
- W2150536616 startingPage "1375" @default.
- W2150536616 abstract "Renal epithelial cells must maintain distinct protein compositions in their apical and basolateral membranes in order to perform their transport functions. The creation of these polarized protein distributions depends on sorting signals that designate the trafficking route and site of ultimate functional residence for each protein. Segregation of newly synthesized apical and basolateral proteins into distinct carrier vesicles can occur at the trans-Golgi network, recycling endosomes, or a growing assortment of stations along the cellular trafficking pathway. The nature of the specific sorting signal and the mechanism through which it is interpreted can influence the route a protein takes through the cell. Cell type-specific variations in the targeting motifs of a protein, as are evident for Na,K-ATPase, demonstrate a remarkable capacity to adapt sorting pathways to different developmental states or physiologic requirements. This review summarizes our current understanding of apical and basolateral trafficking routes in polarized epithelial cells." @default.
- W2150536616 created "2016-06-24" @default.
- W2150536616 creator A5041557565 @default.
- W2150536616 creator A5079333329 @default.
- W2150536616 date "2014-03-20" @default.
- W2150536616 modified "2023-10-18" @default.
- W2150536616 title "Trafficking to the Apical and Basolateral Membranes in Polarized Epithelial Cells" @default.
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