FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150543200> ?p ?o ?g. }

• W2150543200 endingPage "411" @default.
• W2150543200 startingPage "404" @default.
• W2150543200 abstract "Tramadol is a centrally acting analgesic that demonstrates opioid and monoaminergic properties. Several studies have suggested that tramadol could play a role in mood improvement. Moreover, it has previously been shown that tramadol is effective in the forced swimming test in mice and the learned helplessness model in rats, two behavioural modelspredictive of antidepressant activity. The aim of the present study was to test tramadol and its enantiomers in the reserpine test in mice, aclassical observational test widely used in the screening of antidepressant drugs. This test is a non-behavioural method where only objective parameters such as rectal temperature and palprebral ptosis are considered. Moreover, we compared the effects of tramadol and itsenantiomers with those of antidepressants (desipramine, fluvoxamine and venlafaxine) and opiates [morphine (–)-methadone and levorphanol]. Racemic tramadol, (–)-tramadol, desipramine and venlafaxine reversed the reserpine syndrome (rectal temperature and ptosis), whereas(+)-tramadol and fluvoxamine only antagonized the reserpine-induced ptosis, without any effect on temperature. Opiates did not reversereserpine-induced hypothermia. (–)-Methadone showed slight effects regarding reserpine-induced ptosis, morphine and levorphanol had no effect. These results show that tramadol has an effect comparable to clinically effective antidepressants in a test predictive of antidepressant activity, without behavioural implications. Together with other clinical and experimental data, this suggests that tramadol has an inherent antidepressant-like (mood improving) activity, and that this effect could have clinical repercussions on the affective component of pain." @default.
• W2150543200 created "2016-06-24" @default.
• W2150543200 creator A5005951432 @default.
• W2150543200 creator A5026735143 @default.
• W2150543200 creator A5070426401 @default.
• W2150543200 creator A5082903993 @default.
• W2150543200 date "2004-09-01" @default.
• W2150543200 modified "2023-09-26" @default.
• W2150543200 title "Antidepressant-Like Effect of tramadol and its Enantiomers in Reserpinized Mice: Comparativestudy with Desipramine, Fluvoxamine, Venlafaxine and Opiates" @default.
• W2150543200 cites W1968122055 @default.
• W2150543200 cites W1971162866 @default.
• W2150543200 cites W1976258142 @default.
• W2150543200 cites W1979459872 @default.
• W2150543200 cites W1983972036 @default.
• W2150543200 cites W1986785763 @default.
• W2150543200 cites W2000541904 @default.
• W2150543200 cites W2007791604 @default.
• W2150543200 cites W2009185989 @default.
• W2150543200 cites W2015155346 @default.
• W2150543200 cites W2033912659 @default.
• W2150543200 cites W2037016502 @default.
• W2150543200 cites W2037043191 @default.
• W2150543200 cites W2045108246 @default.
• W2150543200 cites W2062225153 @default.
• W2150543200 cites W2063621859 @default.
• W2150543200 cites W2066702812 @default.
• W2150543200 cites W2071289233 @default.
• W2150543200 cites W2078098101 @default.
• W2150543200 cites W2079001561 @default.
• W2150543200 cites W2080477987 @default.
• W2150543200 cites W2085272519 @default.
• W2150543200 cites W2154923381 @default.
• W2150543200 cites W2159745586 @default.
• W2150543200 cites W4239720593 @default.
• W2150543200 cites W87067304 @default.
• W2150543200 doi "https://doi.org/10.1177/026988110401800305" @default.
• W2150543200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15358985" @default.
• W2150543200 hasPublicationYear "2004" @default.
• W2150543200 type Work @default.
• W2150543200 sameAs 2150543200 @default.
• W2150543200 citedByCount "49" @default.
• W2150543200 countsByYear W21505432002012 @default.
• W2150543200 countsByYear W21505432002013 @default.
• W2150543200 countsByYear W21505432002014 @default.
• W2150543200 countsByYear W21505432002015 @default.
• W2150543200 countsByYear W21505432002016 @default.
• W2150543200 countsByYear W21505432002017 @default.
• W2150543200 countsByYear W21505432002018 @default.
• W2150543200 countsByYear W21505432002019 @default.
• W2150543200 countsByYear W21505432002020 @default.
• W2150543200 countsByYear W21505432002021 @default.
• W2150543200 countsByYear W21505432002022 @default.
• W2150543200 crossrefType "journal-article" @default.
• W2150543200 hasAuthorship W2150543200A5005951432 @default.
• W2150543200 hasAuthorship W2150543200A5026735143 @default.
• W2150543200 hasAuthorship W2150543200A5070426401 @default.
• W2150543200 hasAuthorship W2150543200A5082903993 @default.
• W2150543200 hasConcept C118552586 @default.
• W2150543200 hasConcept C126322002 @default.
• W2150543200 hasConcept C136569192 @default.
• W2150543200 hasConcept C15744967 @default.
• W2150543200 hasConcept C170493617 @default.
• W2150543200 hasConcept C2775864247 @default.
• W2150543200 hasConcept C2776134451 @default.
• W2150543200 hasConcept C2776466888 @default.
• W2150543200 hasConcept C2778750930 @default.
• W2150543200 hasConcept C2779177272 @default.
• W2150543200 hasConcept C2779248205 @default.
• W2150543200 hasConcept C2779777798 @default.
• W2150543200 hasConcept C2779910183 @default.
• W2150543200 hasConcept C2780250439 @default.
• W2150543200 hasConcept C2780820201 @default.
• W2150543200 hasConcept C2781063702 @default.
• W2150543200 hasConcept C31487548 @default.
• W2150543200 hasConcept C42219234 @default.
• W2150543200 hasConcept C558461103 @default.
• W2150543200 hasConcept C71924100 @default.
• W2150543200 hasConcept C98274493 @default.
• W2150543200 hasConceptScore W2150543200C118552586 @default.
• W2150543200 hasConceptScore W2150543200C126322002 @default.
• W2150543200 hasConceptScore W2150543200C136569192 @default.
• W2150543200 hasConceptScore W2150543200C15744967 @default.
• W2150543200 hasConceptScore W2150543200C170493617 @default.
• W2150543200 hasConceptScore W2150543200C2775864247 @default.
• W2150543200 hasConceptScore W2150543200C2776134451 @default.
• W2150543200 hasConceptScore W2150543200C2776466888 @default.
• W2150543200 hasConceptScore W2150543200C2778750930 @default.
• W2150543200 hasConceptScore W2150543200C2779177272 @default.
• W2150543200 hasConceptScore W2150543200C2779248205 @default.
• W2150543200 hasConceptScore W2150543200C2779777798 @default.
• W2150543200 hasConceptScore W2150543200C2779910183 @default.
• W2150543200 hasConceptScore W2150543200C2780250439 @default.
• W2150543200 hasConceptScore W2150543200C2780820201 @default.
• W2150543200 hasConceptScore W2150543200C2781063702 @default.
• W2150543200 hasConceptScore W2150543200C31487548 @default.
• W2150543200 hasConceptScore W2150543200C42219234 @default.
• W2150543200 hasConceptScore W2150543200C558461103 @default.
• W2150543200 hasConceptScore W2150543200C71924100 @default.

• next