FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150552914> ?p ?o ?g. }

• W2150552914 endingPage "e101957" @default.
• W2150552914 startingPage "e101957" @default.
• W2150552914 abstract "Sporadic colorectal cancer (CRC) is a common malignancy and also one of the main causes of cancer deaths worldwide. Aberrant expression of the transcription factor SOX2 has recently been observed in several cancer types, but its role in CRC has not been fully elucidated. Here we studied the expression of SOX2 in 441 CRC patients by immunohistochemistry and related the expression to clinicopathological and molecular variables and patient prognosis. SOX2 was expressed in 11% of the tumors and was significantly associated to BRAFV600E mutation, but not to KRAS mutations (codon 12 and 13). SOX2 positivity was correlated to poor patient survival, especially in BRAFV600E mutated cases. In vitro studies showed that cells expressing the constitutively active BRAFV600E had increased SOX2 expression, a finding not found in cells expressing KRASG12V. Furthermore, blocking downstream BRAF signalling using a MEK-inhibitor resulted in a decreased expression of SOX2. Since SOX2 overexpression has been correlated to increased migration and invasion, we investigated the SOX2 expression in human CRC liver metastasis and found that a SOX2 positive primary CRC also had SOX2 expression in corresponding liver metastases. Finally we found that cells overexpressing SOX2 in vitro showed enhanced expression of FGFR1, which has been reported to correlate with liver metastasis in CRC. Our novel findings suggest that SOX2 expression is partly regulated by BRAF signalling, and an increased SOX2 expression may promote CRC metastasis and mediate a poor patient prognosis." @default.
• W2150552914 created "2016-06-24" @default.
• W2150552914 creator A5009484745 @default.
• W2150552914 creator A5023810481 @default.
• W2150552914 creator A5029143535 @default.
• W2150552914 creator A5030892575 @default.
• W2150552914 creator A5048120660 @default.
• W2150552914 creator A5053072874 @default.
• W2150552914 creator A5062647369 @default.
• W2150552914 creator A5087196174 @default.
• W2150552914 date "2014-07-10" @default.
• W2150552914 modified "2023-09-27" @default.
• W2150552914 title "SOX2 Expression Is Regulated by BRAF and Contributes to Poor Patient Prognosis in Colorectal Cancer" @default.
• W2150552914 cites W1525985826 @default.
• W2150552914 cites W1969394448 @default.
• W2150552914 cites W1971517727 @default.
• W2150552914 cites W1975131304 @default.
• W2150552914 cites W1975930864 @default.
• W2150552914 cites W1983040612 @default.
• W2150552914 cites W1985267763 @default.
• W2150552914 cites W1988476050 @default.
• W2150552914 cites W2001258296 @default.
• W2150552914 cites W2004396122 @default.
• W2150552914 cites W2007420407 @default.
• W2150552914 cites W2013975797 @default.
• W2150552914 cites W2014874263 @default.
• W2150552914 cites W2017598170 @default.
• W2150552914 cites W2029372290 @default.
• W2150552914 cites W2044303467 @default.
• W2150552914 cites W2049884783 @default.
• W2150552914 cites W2058646321 @default.
• W2150552914 cites W2064543601 @default.
• W2150552914 cites W2064854706 @default.
• W2150552914 cites W2073759231 @default.
• W2150552914 cites W2074406343 @default.
• W2150552914 cites W2092294650 @default.
• W2150552914 cites W2100543432 @default.
• W2150552914 cites W2112180493 @default.
• W2150552914 cites W2113559596 @default.
• W2150552914 cites W2115276344 @default.
• W2150552914 cites W2117424291 @default.
• W2150552914 cites W2122447839 @default.
• W2150552914 cites W2123349002 @default.
• W2150552914 cites W2125987139 @default.
• W2150552914 cites W2129566355 @default.
• W2150552914 cites W2148394396 @default.
• W2150552914 cites W2165132869 @default.
• W2150552914 cites W2169529166 @default.
• W2150552914 cites W2169903102 @default.
• W2150552914 cites W2171777194 @default.
• W2150552914 doi "https://doi.org/10.1371/journal.pone.0101957" @default.
• W2150552914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4092103" @default.
• W2150552914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25010701" @default.
• W2150552914 hasPublicationYear "2014" @default.
• W2150552914 type Work @default.
• W2150552914 sameAs 2150552914 @default.
• W2150552914 citedByCount "44" @default.
• W2150552914 countsByYear W21505529142015 @default.
• W2150552914 countsByYear W21505529142016 @default.
• W2150552914 countsByYear W21505529142017 @default.
• W2150552914 countsByYear W21505529142018 @default.
• W2150552914 countsByYear W21505529142019 @default.
• W2150552914 countsByYear W21505529142020 @default.
• W2150552914 countsByYear W21505529142021 @default.
• W2150552914 countsByYear W21505529142022 @default.
• W2150552914 crossrefType "journal-article" @default.
• W2150552914 hasAuthorship W2150552914A5009484745 @default.
• W2150552914 hasAuthorship W2150552914A5023810481 @default.
• W2150552914 hasAuthorship W2150552914A5029143535 @default.
• W2150552914 hasAuthorship W2150552914A5030892575 @default.
• W2150552914 hasAuthorship W2150552914A5048120660 @default.
• W2150552914 hasAuthorship W2150552914A5053072874 @default.
• W2150552914 hasAuthorship W2150552914A5062647369 @default.
• W2150552914 hasAuthorship W2150552914A5087196174 @default.
• W2150552914 hasBestOaLocation W21505529141 @default.
• W2150552914 hasConcept C104317684 @default.
• W2150552914 hasConcept C121608353 @default.
• W2150552914 hasConcept C126322002 @default.
• W2150552914 hasConcept C204232928 @default.
• W2150552914 hasConcept C2777933648 @default.
• W2150552914 hasConcept C2779013556 @default.
• W2150552914 hasConcept C2781187634 @default.
• W2150552914 hasConcept C502942594 @default.
• W2150552914 hasConcept C526805850 @default.
• W2150552914 hasConcept C54355233 @default.
• W2150552914 hasConcept C71924100 @default.
• W2150552914 hasConcept C86339819 @default.
• W2150552914 hasConcept C86803240 @default.
• W2150552914 hasConceptScore W2150552914C104317684 @default.
• W2150552914 hasConceptScore W2150552914C121608353 @default.
• W2150552914 hasConceptScore W2150552914C126322002 @default.
• W2150552914 hasConceptScore W2150552914C204232928 @default.
• W2150552914 hasConceptScore W2150552914C2777933648 @default.
• W2150552914 hasConceptScore W2150552914C2779013556 @default.
• W2150552914 hasConceptScore W2150552914C2781187634 @default.
• W2150552914 hasConceptScore W2150552914C502942594 @default.
• W2150552914 hasConceptScore W2150552914C526805850 @default.
• W2150552914 hasConceptScore W2150552914C54355233 @default.

• next