FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2150565546> ?p ?o ?g. }

• W2150565546 endingPage "1430" @default.
• W2150565546 startingPage "1419" @default.
• W2150565546 abstract "Prostaglandins are a class of molecules that mediate cellular inflammatory responses and control cell growth. The oxidative conversion of arachidonic acid to prostaglandin H2 is carried out by two isozymes of cyclooxygenase, COX-1 and COX-2. COX-1 is constitutively expressed, while COX-2 can be transiently induced by external stimuli, such as pro-inflammatory cytokines. Interestingly, COX-2 is overexpressed in numerous cancers, including lung cancer. MicroRNAs (miRNAs) are small RNA molecules that function to regulate gene expression. Previous studies have implicated an important role for miRNAs in human cancer. We demonstrate here that miR-146a expression levels are significantly lower in lung cancer cells as compared with normal lung cells. Conversely, lung cancer cells have higher levels of COX-2 protein and mRNA expression. Introduction of miR-146a can specifically ablate COX-2 protein and the biological activity of COX-2 as measured by prostaglandin production. The regulation of COX-2 by miR-146a is mediated through a single miRNA-binding site present in the 3' UTR. Therefore, we propose that decreased miR-146a expression contributes to the up-regulation and overexpression of COX-2 in lung cancer cells. Since potential miRNA-mediated regulation is a functional consequence of alternative polyadenylation site choice, understanding the molecular mechanisms that regulate COX-2 mRNA alternative polyadenylation and miRNA targeting will give us key insights into how COX-2 expression is involved in the development of a metastatic condition." @default.
• W2150565546 created "2016-06-24" @default.
• W2150565546 creator A5034453343 @default.
• W2150565546 creator A5035785741 @default.
• W2150565546 date "2014-07-21" @default.
• W2150565546 modified "2023-10-16" @default.
• W2150565546 title "Regulation of COX-2 expression by miR-146a in lung cancer cells" @default.
• W2150565546 cites W144423133 @default.
• W2150565546 cites W1536031017 @default.
• W2150565546 cites W1545465585 @default.
• W2150565546 cites W1637759799 @default.
• W2150565546 cites W1975560535 @default.
• W2150565546 cites W1976372129 @default.
• W2150565546 cites W1991544505 @default.
• W2150565546 cites W1993210207 @default.
• W2150565546 cites W2002995168 @default.
• W2150565546 cites W2003437276 @default.
• W2150565546 cites W2007485570 @default.
• W2150565546 cites W2023620453 @default.
• W2150565546 cites W2029706883 @default.
• W2150565546 cites W2045770017 @default.
• W2150565546 cites W2051654549 @default.
• W2150565546 cites W2054217012 @default.
• W2150565546 cites W2054872303 @default.
• W2150565546 cites W2058118671 @default.
• W2150565546 cites W2059339710 @default.
• W2150565546 cites W2062666108 @default.
• W2150565546 cites W2064124917 @default.
• W2150565546 cites W2068918704 @default.
• W2150565546 cites W2072378401 @default.
• W2150565546 cites W2072696221 @default.
• W2150565546 cites W2075860675 @default.
• W2150565546 cites W2081835397 @default.
• W2150565546 cites W2086510997 @default.
• W2150565546 cites W2098126158 @default.
• W2150565546 cites W2100651747 @default.
• W2150565546 cites W2115613198 @default.
• W2150565546 cites W2117218214 @default.
• W2150565546 cites W2117692326 @default.
• W2150565546 cites W2124816777 @default.
• W2150565546 cites W2132579331 @default.
• W2150565546 cites W2133094898 @default.
• W2150565546 cites W2136059996 @default.
• W2150565546 cites W2142801414 @default.
• W2150565546 cites W2149233326 @default.
• W2150565546 cites W2150092010 @default.
• W2150565546 cites W2157155706 @default.
• W2150565546 cites W2157412837 @default.
• W2150565546 cites W2157843092 @default.
• W2150565546 cites W2159973565 @default.
• W2150565546 cites W2161817637 @default.
• W2150565546 cites W224920018 @default.
• W2150565546 cites W2417387713 @default.
• W2150565546 cites W4243831921 @default.
• W2150565546 cites W4244040099 @default.
• W2150565546 cites W537897 @default.
• W2150565546 doi "https://doi.org/10.1261/rna.044149.113" @default.
• W2150565546 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4138325" @default.
• W2150565546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047043" @default.
• W2150565546 hasPublicationYear "2014" @default.
• W2150565546 type Work @default.
• W2150565546 sameAs 2150565546 @default.
• W2150565546 citedByCount "60" @default.
• W2150565546 countsByYear W21505655462015 @default.
• W2150565546 countsByYear W21505655462016 @default.
• W2150565546 countsByYear W21505655462017 @default.
• W2150565546 countsByYear W21505655462018 @default.
• W2150565546 countsByYear W21505655462019 @default.
• W2150565546 countsByYear W21505655462020 @default.
• W2150565546 countsByYear W21505655462021 @default.
• W2150565546 countsByYear W21505655462022 @default.
• W2150565546 countsByYear W21505655462023 @default.
• W2150565546 crossrefType "journal-article" @default.
• W2150565546 hasAuthorship W2150565546A5034453343 @default.
• W2150565546 hasAuthorship W2150565546A5035785741 @default.
• W2150565546 hasBestOaLocation W21505655461 @default.
• W2150565546 hasConcept C104317684 @default.
• W2150565546 hasConcept C105580179 @default.
• W2150565546 hasConcept C121608353 @default.
• W2150565546 hasConcept C126322002 @default.
• W2150565546 hasConcept C145059251 @default.
• W2150565546 hasConcept C150194340 @default.
• W2150565546 hasConcept C181199279 @default.
• W2150565546 hasConcept C2776256026 @default.
• W2150565546 hasConcept C2779689624 @default.
• W2150565546 hasConcept C2780978440 @default.
• W2150565546 hasConcept C502942594 @default.
• W2150565546 hasConcept C54355233 @default.
• W2150565546 hasConcept C55493867 @default.
• W2150565546 hasConcept C71924100 @default.
• W2150565546 hasConcept C86803240 @default.
• W2150565546 hasConcept C95444343 @default.
• W2150565546 hasConceptScore W2150565546C104317684 @default.
• W2150565546 hasConceptScore W2150565546C105580179 @default.
• W2150565546 hasConceptScore W2150565546C121608353 @default.
• W2150565546 hasConceptScore W2150565546C126322002 @default.
• W2150565546 hasConceptScore W2150565546C145059251 @default.
• W2150565546 hasConceptScore W2150565546C150194340 @default.

• next